Liver X receptor: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (5 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load=' | <StructureSection load='' size='350' side='right' caption='Human liver X receptor β ligand binding domain (deepskyblue) complex with retinoic X receptor β (green) and modulator (PDB code [[5kya]])' scene='77/776388/Cv/1'> | ||
| Line 5: | Line 5: | ||
'''Liver X receptors''' (LXR) are ligand-activated transcription factors of the nuclear receptor family. There are two LXR isoforms α and β which form heterodimers with retinoic X receptor upon activation and bind to the LXR response element found in the promoter region of the target genes<ref>PMID:19258656</ref>. LXR is a lipogenic transcription factor<ref>PMID:17107947</ref>. LXRs modulate the expression of genes in cholesterol and lipid metabolism in response to changes in cellular cholesterol status. | '''Liver X receptors''' (LXR) are ligand-activated transcription factors of the nuclear receptor family. There are two LXR isoforms α and β which form heterodimers with retinoic X receptor upon activation and bind to the LXR response element found in the promoter region of the target genes<ref>PMID:19258656</ref>. LXR is a lipogenic transcription factor<ref>PMID:17107947</ref>. LXRs modulate the expression of genes in cholesterol and lipid metabolism in response to changes in cellular cholesterol status. | ||
*'''Liver X receptor alpha''' has a role in regulating innate immunity at the genomic level. | |||
*'''Liver X receptor beta''' is an important transcription factor promoting the survival of single-positive thymocytes<ref>PMID:32963358</ref>. | |||
See also [[Intracellular receptors]] | |||
== Disease == | == Disease == | ||
| Line 25: | Line 30: | ||
* Liver X receptor α | * Liver X receptor α | ||
**[[5avl]], [[5avl]], [[5hjs]], [[3ipq]], [[3ips]], [[3ipu]] – hLXR LBD + NCOA-1 peptide + agonist - human<br /> | |||
**[[1uhl]] – hLXR LBD + retinoic X receptor β + NCOA-2 <br /> | |||
**[[2acl]] – mLXR + retinoic X receptor α + agonist – mouse <br /> | **[[2acl]] – mLXR + retinoic X receptor α + agonist – mouse <br /> | ||
* Liver X receptor β | * Liver X receptor β | ||
**[[1upv]], [[1upw]], [[5jy3]], [[3kfc]], [[4rak]] – hLXR LBD + agonist – | **[[1upv]], [[1upw]], [[5jy3]], [[3kfc]], [[4rak]], [[6s4n]], [[6s4t]], [[6s4u]], [[6s5k]] – hLXR LBD + agonist<br /> | ||
**[[6k9g]], [[6k9h]], [[6k9m]] – hLXR LBD (mutant) + agonist <br /> | |||
**[[1pq6]], [[1pqc]], [[1pq9]] – hLXR LBD + ligand<br /> | **[[1pq6]], [[1pqc]], [[1pq9]] – hLXR LBD + ligand<br /> | ||
**[[6jio]] – hLXR LBD (mutant) + ligand<br /> | |||
**[[5i4v]] – hLXR LBD + retinoic X receptor β + agonist <br /> | **[[5i4v]] – hLXR LBD + retinoic X receptor β + agonist <br /> | ||
**[[5kyj]], [[5kya]] – hLXR LBD + retinoic X receptor β + modulator <br /> | **[[5kyj]], [[5kya]] – hLXR LBD + retinoic X receptor β + modulator <br /> | ||