Liver X receptor: Difference between revisions
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<StructureSection load=' | <StructureSection load='' size='350' side='right' caption='Human liver X receptor β ligand binding domain (deepskyblue) complex with retinoic X receptor β (green) and modulator (PDB code [[5kya]])' scene='77/776388/Cv/1'> | ||
== Function == | == Function == | ||
'''Liver X | '''Liver X receptors''' (LXR) are ligand-activated transcription factors of the nuclear receptor family. There are two LXR isoforms α and β which form heterodimers with retinoic X receptor upon activation and bind to the LXR response element found in the promoter region of the target genes<ref>PMID:19258656</ref>. LXR is a lipogenic transcription factor<ref>PMID:17107947</ref>. LXRs modulate the expression of genes in cholesterol and lipid metabolism in response to changes in cellular cholesterol status. | ||
*'''Liver X receptor alpha''' has a role in regulating innate immunity at the genomic level. | |||
*'''Liver X receptor beta''' is an important transcription factor promoting the survival of single-positive thymocytes<ref>PMID:32963358</ref>. | |||
See also [[Intracellular receptors]] | |||
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
LXR modulator binds to the LXR in the LXR/retinoic X receptor β heterodimer in a hydrophobic pocket<ref>PMID:27599745</ref>. | <scene name='77/776388/Cv/2'>Human liver X receptor β ligand binding domain complex with retinoic X receptor β and modulator</scene>. LXR <scene name='77/776388/Cv/4'>modulator binds to the LXR</scene> in the LXR/retinoic X receptor β heterodimer in a hydrophobic <scene name='77/776388/Cv/5'>pocket</scene><ref>PMID:27599745</ref>. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of liver X | == 3D Structures of liver X receptor == | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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* Liver X receptor α | * Liver X receptor α | ||
**[[5avl]], [[5avl]], [[5hjs]], [[3ipq]], [[3ips]], [[3ipu]] – hLXR LBD + NCOA-1 peptide + agonist - human<br /> | |||
**[[1uhl]] – hLXR LBD + retinoic X receptor β + NCOA-2 <br /> | |||
**[[2acl]] – mLXR + retinoic X receptor α + agonist – mouse <br /> | **[[2acl]] – mLXR + retinoic X receptor α + agonist – mouse <br /> | ||
* Liver X receptor β | * Liver X receptor β | ||
**[[1upv]], [[1upw]], [[5jy3]], [[3kfc]], [[4rak]] – hLXR LBD + agonist – | **[[1upv]], [[1upw]], [[5jy3]], [[3kfc]], [[4rak]], [[6s4n]], [[6s4t]], [[6s4u]], [[6s5k]] – hLXR LBD + agonist<br /> | ||
**[[6k9g]], [[6k9h]], [[6k9m]] – hLXR LBD (mutant) + agonist <br /> | |||
**[[1pq6]], [[1pqc]], [[1pq9]] – hLXR LBD + ligand<br /> | **[[1pq6]], [[1pqc]], [[1pq9]] – hLXR LBD + ligand<br /> | ||
**[[6jio]] – hLXR LBD (mutant) + ligand<br /> | |||
**[[5i4v]] – hLXR LBD + retinoic X receptor β + agonist <br /> | **[[5i4v]] – hLXR LBD + retinoic X receptor β + agonist <br /> | ||
**[[5kyj]], [[5kya]] – hLXR LBD + retinoic X receptor β + modulator <br /> | **[[5kyj]], [[5kya]] – hLXR LBD + retinoic X receptor β + modulator <br /> | ||
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**[[5hjp]] – hLXR LBD + retinoic X receptor β + agonist<br /> | **[[5hjp]] – hLXR LBD + retinoic X receptor β + agonist<br /> | ||
**[[4nqa]] – hLXR LBD + retinoic X receptor β + NCOA-2 peptide + DNA <br /> | **[[4nqa]] – hLXR LBD + retinoic X receptor β + NCOA-2 peptide + DNA <br /> | ||
**[[4dk7]], [[4dk8]] – hLXR LBD + NCOA-1 peptide + agonist<br /> | **[[4dk7]], [[4dk8]], [[5avi]] – hLXR LBD + NCOA-1 peptide + agonist<br /> | ||
**[[1p8d]] – hLXR LBD + NCOA-1 peptide + cholesterol derivative<br /> | **[[1p8d]] – hLXR LBD + NCOA-1 peptide + cholesterol derivative<br /> | ||
**[[3l0e]] – hLXR LBD + NCOA-2 peptide + inhibitor<br /> | |||
}} | }} | ||
== References == | == References == | ||