Liver X receptor: Difference between revisions

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New page: <StructureSection load='1stp' size='340' side='right' caption='liver X receptpr' scene=''> == Function == liver X receptpr (LXR) <ref>PMID:12906827</ref> == Disease == == Relevance ==...
 
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<StructureSection load='' size='350' side='right' caption='Human liver X receptor β ligand binding domain (deepskyblue) complex with retinoic X receptor β (green) and modulator (PDB code [[5kya]])' scene='77/776388/Cv/1'>


<StructureSection load='1stp' size='340' side='right' caption='liver X receptpr' scene=''>


== Function ==
'''Liver X receptors''' (LXR) are ligand-activated transcription factors of the nuclear receptor family.  There are two LXR isoforms α and β which form heterodimers with retinoic X receptor upon activation and bind to the LXR response element found in the promoter region of the target genes<ref>PMID:19258656</ref>.  LXR is a lipogenic transcription factor<ref>PMID:17107947</ref>.  LXRs modulate the expression of genes in cholesterol and lipid metabolism in response to changes in cellular cholesterol status.
*'''Liver X receptor alpha''' has a role in regulating innate immunity at the genomic level.
*'''Liver X receptor beta''' is an important transcription factor promoting the survival of single-positive thymocytes<ref>PMID:32963358</ref>.


== Function ==
See also [[Intracellular receptors]]


liver X receptpr (LXR)
<ref>PMID:12906827</ref>
== Disease ==
== Disease ==
Treatment of mice demonstrating Wilson disease with LXR agonist reduced disease manifestations without worsening neurological symptoms associated with the conventional therapy based on copper chelation<ref>PMID:26679751</ref>. 


== Relevance ==
== Relevance ==
LXRs have emerged as promising drug targets for anti-atherosclerotic therapies<ref>PMID:20363253</ref>.


== Structural highlights ==
== Structural highlights ==


 
<scene name='77/776388/Cv/2'>Human liver X receptor β ligand binding domain complex with retinoic X receptor β and modulator</scene>. LXR <scene name='77/776388/Cv/4'>modulator binds to the LXR</scene> in the LXR/retinoic X receptor β heterodimer in a hydrophobic <scene name='77/776388/Cv/5'>pocket</scene><ref>PMID:27599745</ref>.
</StructureSection>
</StructureSection>
== 3D Structures of liver X receptpr ==
== 3D Structures of liver X receptor ==


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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|


* Liver X receptor alpha
* Liver X receptor α


**[[2acl]] – mLXR + retinoic X receptor alpha + agonist – mouse <br />
**[[5avl]], [[5avl]], [[5hjs]], [[3ipq]], [[3ips]], [[3ipu]] – hLXR LBD + NCOA-1 peptide + agonist - human<br />
**[[5avl]], [[5avl]], [[5hjs]], [[3ipq]], [[3ips]], [[3ipu]] – hLXR LBD + NCOA-1 peptide + agonist<br />
**[[1uhl]] – hLXR LBD + retinoic X receptor β + NCOA-2 <br />
**[[1uhl]] – hLXR LBD + retinoic X receptor beta + NCOA-2 <br />
**[[2acl]] – mLXR + retinoic X receptor α + agonist – mouse <br />


* Liver X receptor beta
* Liver X receptor β


**[[1upv]], [[1upw]], [[5jy3]], [[3kfc]], [[4rak]] – hLXR LBD + agonist – human<br />
**[[1upv]], [[1upw]], [[5jy3]], [[3kfc]], [[4rak]], [[6s4n]], [[6s4t]], [[6s4u]], [[6s5k]] – hLXR LBD + agonist<br />
**[[6k9g]], [[6k9h]], [[6k9m]] hLXR LBD (mutant) + agonist <br />
**[[1pq6]], [[1pqc]], [[1pq9]] – hLXR LBD + ligand<br />
**[[1pq6]], [[1pqc]], [[1pq9]] – hLXR LBD + ligand<br />
**[[5i4v]] – hLXR LBD + retinoic X receptor beta + agonist <br />
**[[6jio]] – hLXR LBD (mutant) + ligand<br />
**[[5kyj]], [[5kya]] – hLXR LBD + retinoic X receptor beta + modulator <br />
**[[5i4v]] – hLXR LBD + retinoic X receptor β + agonist <br />
**[[3fal]] – hLXR LBD + retinoic X receptor beta + modulator + retinoic acid<br />
**[[5kyj]], [[5kya]] – hLXR LBD + retinoic X receptor β + modulator <br />
**[[5hjp]] – hLXR LBD + retinoic X receptor beta + agonist<br />
**[[3fal]] – hLXR LBD + retinoic X receptor β + modulator + retinoic acid<br />
**[[4nqa]] – hLXR LBD + retinoic X receptor beta + NCOA-2 peptide + DNA <br />
**[[5hjp]] – hLXR LBD + retinoic X receptor β + agonist<br />
**[[4dk7]], [[4dk8]] – hLXR LBD + NCOA-1 peptide + agonist<br />
**[[4nqa]] – hLXR LBD + retinoic X receptor β + NCOA-2 peptide + DNA <br />
**[[4dk7]], [[4dk8]], [[5avi]] – hLXR LBD + NCOA-1 peptide + agonist<br />
**[[1p8d]] – hLXR LBD + NCOA-1 peptide + cholesterol derivative<br />
**[[1p8d]] – hLXR LBD + NCOA-1 peptide + cholesterol derivative<br />
**[[3l0e]] – hLXR LBD + NCOA-2 peptide + inhibitor<br />
}}
}}
== References ==
== References ==

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Jaime Prilusky, Alexander Berchansky