5neu: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 5neu is ON HOLD  until Paper Publication
+==Localised Reconstruction of Integrin alpha V beta 6 bound to Foot and Mouth Disease Virus O1 Manisa - Pose B.==
+<SX load='5neu' size='340' side='right' viewer='molstar' caption='[[5neu]], [[Resolution|resolution]] 12.30&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5neu]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Foot-and-mouth_disease_virus Foot-and-mouth disease virus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NEU FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 12.3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5neu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5neu OCA], [https://pdbe.org/5neu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5neu RCSB], [https://www.ebi.ac.uk/pdbsum/5neu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5neu ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/D1H101_9PICO D1H101_9PICO]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Foot-and-mouth disease virus (FMDV) mediates cell entry by attachment to an integrin receptor, generally alphavbeta6, via a conserved arginine-glycine-aspartic acid (RGD) motif in the exposed, antigenic, GH loop of capsid protein VP1. Infection can also occur in tissue culture adapted virus in the absence of integrin via acquired basic mutations interacting with heparin sulphate (HS); this virus is attenuated in natural infections. HS interaction has been visualized at a conserved site in two serotypes suggesting a propensity for sulfated-sugar binding. Here we determined the interaction between alphavbeta6 and two tissue culture adapted FMDV strains by cryo-electron microscopy. In the preferred mode of engagement, the fully open form of the integrin, hitherto unseen at high resolution, attaches to an extended GH loop via interactions with the RGD motif plus downstream hydrophobic residues. In addition, an N-linked sugar of the integrin attaches to the previously identified HS binding site, suggesting a functional role.
-Authors: Kotecha, A., Stuart, D.
+Rules of engagement between alphavbeta6 integrin and foot-and-mouth disease virus.,Kotecha A, Wang Q, Dong X, Ilca SL, Ondiviela M, Zihe R, Seago J, Charleston B, Fry EE, Abrescia NGA, Springer TA, Huiskonen JT, Stuart DI Nat Commun. 2017 May 23;8:15408. doi: 10.1038/ncomms15408. PMID:28534487<ref>PMID:28534487</ref>
-Description: Localised Reconstruction of Integrin alpha v beta 6 bound to Foot and Mouth Disease Virus O1 Manisa -Pose B
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Stuart, D]]
+<div class="pdbe-citations 5neu" style="background-color:#fffaf0;"></div>
-[[Category: Kotecha, A]]
+==See Also==
+*[[Integrin 3D structures|Integrin 3D structures]]
+== References ==
+<references/>
+__TOC__
+</SX>
+[[Category: Foot-and-mouth disease virus]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Kotecha A]]
+[[Category: Stuart D]]