5tkl: Difference between revisions

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 <StructureSection load='5tkl' size='340' side='right'caption='[[5tkl]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5tkl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TKL FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5tkl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TKL FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene>, <scene name='pdbligand=G3H:GLYCERALDEHYDE-3-PHOSPHATE'>G3H</scene>, <scene name='pdbligand=P6F:1,6-DI-O-PHOSPHONO-D-FRUCTOSE'>P6F</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.751&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5tjs|5tjs]], [[5tk3|5tk3]], [[5tkc|5tkc]], [[5tkn|5tkn]], [[5tkp|5tkp]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=13P:1,3-DIHYDROXYACETONEPHOSPHATE'>13P</scene>, <scene name='pdbligand=G3H:GLYCERALDEHYDE-3-PHOSPHATE'>G3H</scene>, <scene name='pdbligand=P6F:1,6-DI-O-PHOSPHONO-D-FRUCTOSE'>P6F</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ald-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 TOXGO])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tkl OCA], [https://pdbe.org/5tkl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tkl RCSB], [https://www.ebi.ac.uk/pdbsum/5tkl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tkl ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tkl OCA], [http://pdbe.org/5tkl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tkl RCSB], [http://www.ebi.ac.uk/pdbsum/5tkl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tkl ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/ALF1_TOXGO ALF1_TOXGO] Plays a key role in glycolysis by catalyzing the cleavage of fructose 1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate (PubMed:19380114, PubMed:25284756, PubMed:28972169). Forms a bridge between cell surface adhesins and the actin cytoskeleton (PubMed:12718875, PubMed:19380114). Required for parasite invasion of host cells (PubMed:19380114).<ref>PMID:12718875</ref> <ref>PMID:19380114</ref> <ref>PMID:25284756</ref> <ref>PMID:28972169</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 __TOC__
 </StructureSection>
-[[Category: Fructose-bisphosphate aldolase]]
 [[Category: Large Structures]]
-[[Category: Toxgo]]
+[[Category: Toxoplasma gondii]]
-[[Category: Heron, P W]]
+[[Category: Heron PW]]
-[[Category: Sygusch, J]]
+[[Category: Sygusch J]]
-[[Category: Aldolase]]
-[[Category: Covalent]]
-[[Category: Enamine]]
-[[Category: Glycolysis]]
-[[Category: Intermediate]]
-[[Category: Lyase]]
-[[Category: Schiff base]]
-[[Category: Substrate]]
-[[Category: Tim barrel]]