5lxj: Difference between revisions
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==Solution NMR structure of the X domain of Peste des Petits Ruminants phosphoprotein== | |||
<StructureSection load='5lxj' size='340' side='right'caption='[[5lxj]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5lxj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Morbillivirus_caprinae Morbillivirus caprinae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LXJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lxj OCA], [https://pdbe.org/5lxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lxj RCSB], [https://www.ebi.ac.uk/pdbsum/5lxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lxj ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/PHOSP_PPRV PHOSP_PPRV] Essential cofactor of the RNA polymerase L that plays a central role in the transcription and replication by forming the polymerase complex with RNA polymerase L and recruiting L to the genomic N-RNA template for RNA synthesis (By similarity). Plays also a central role in the encapsidation of nascent RNA chains by forming the encapsidation complex with the nucleocapsid protein N (N-P complex). Acts as a chaperone for newly synthesized free N protein, so-called N0, allowing encapsidation of nascent RNA chains during replication (By similarity). The nucleoprotein protein N prevents excessive phosphorylation of P, which leads to down-regulation of viral transcription/ replication. Participates, together with N, in the formation of viral factories (viroplasms), which are large inclusions in the host cytoplasm where replication takes place (By similarity).[UniProtKB:P06162][UniProtKB:Q77M42] | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Morbillivirus caprinae]] | |||
[[Category: Bontems F]] | |||
[[Category: Eleouet J-F]] | |||
[[Category: Pereira N]] | |||
[[Category: Piuzzi M]] | |||
[[Category: Sizun C]] | |||
Latest revision as of 09:02, 19 June 2024
Solution NMR structure of the X domain of Peste des Petits Ruminants phosphoproteinSolution NMR structure of the X domain of Peste des Petits Ruminants phosphoprotein
Structural highlights
FunctionPHOSP_PPRV Essential cofactor of the RNA polymerase L that plays a central role in the transcription and replication by forming the polymerase complex with RNA polymerase L and recruiting L to the genomic N-RNA template for RNA synthesis (By similarity). Plays also a central role in the encapsidation of nascent RNA chains by forming the encapsidation complex with the nucleocapsid protein N (N-P complex). Acts as a chaperone for newly synthesized free N protein, so-called N0, allowing encapsidation of nascent RNA chains during replication (By similarity). The nucleoprotein protein N prevents excessive phosphorylation of P, which leads to down-regulation of viral transcription/ replication. Participates, together with N, in the formation of viral factories (viroplasms), which are large inclusions in the host cytoplasm where replication takes place (By similarity).[UniProtKB:P06162][UniProtKB:Q77M42] |
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