5kvg: Difference between revisions

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 ==Zika specific antibody, ZV-67, bound to ZIKA envelope DIII==
-<StructureSection load='5kvg' size='340' side='right' caption='[[5kvg]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
+<StructureSection load='5kvg' size='340' side='right'caption='[[5kvg]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5kvg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KVG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KVG FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5kvg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Zika_virus Zika virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KVG FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
-<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kvd|5kvd]], [[5kve|5kve]], [[5kvf|5kvf]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kvg OCA], [https://pdbe.org/5kvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kvg RCSB], [https://www.ebi.ac.uk/pdbsum/5kvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kvg ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kvg OCA], [http://pdbe.org/5kvg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kvg RCSB], [http://www.ebi.ac.uk/pdbsum/5kvg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kvg ProSAT]</span></td></tr>
 </table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Zika virus (ZIKV) infection during pregnancy has emerged as a global public health problem because of its ability to cause severe congenital disease. Here, we developed six mouse monoclonal antibodies (mAbs) against ZIKV including four (ZV-48, ZV-54, ZV-64, and ZV-67) that were ZIKV specific and neutralized infection of African, Asian, and American strains to varying degrees. X-ray crystallographic and competition binding analyses of Fab fragments and scFvs defined three spatially distinct epitopes in DIII of the envelope protein corresponding to the lateral ridge (ZV-54 and ZV-67), C-C' loop (ZV-48 and ZV-64), and ABDE sheet (ZV-2) regions. In vivo passive transfer studies revealed protective activity of DIII-lateral ridge specific neutralizing mAbs in a mouse model of ZIKV infection. Our results suggest that DIII is targeted by multiple type-specific antibodies with distinct neutralizing activity, which provides a path for developing prophylactic antibodies for use in pregnancy or designing epitope-specific vaccines against ZIKV.
+Structural Basis of Zika Virus-Specific Antibody Protection.,Zhao H, Fernandez E, Dowd KA, Speer SD, Platt DJ, Gorman MJ, Govero J, Nelson CA, Pierson TC, Diamond MS, Fremont DH Cell. 2016 Jul 26. pii: S0092-8674(16)30927-8. doi: 10.1016/j.cell.2016.07.020. PMID:27475895<ref>PMID:27475895</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 5kvg" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Antibody 3D structures|Antibody 3D structures]]
+*[[3D structures of non-human antibody|3D structures of non-human antibody]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Structural genomic]]
-[[Category: Fremont, D H]]
-[[Category: Nelson, C A]]
-[[Category: Zhao, H]]
-[[Category: Antibody]]
-[[Category: Csgid]]
-[[Category: Envelope protein]]
-[[Category: Viral protein]]
-[[Category: Viral protein-immune system complex]]
 [[Category: Zika virus]]
+[[Category: Fremont DH]]
+[[Category: Nelson CA]]
+[[Category: Zhao H]]