Monocyte chemoattractant protein: Difference between revisions
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== Function and Structure == | == Function and Structure == | ||
''' | Human synthetic '''monocyte chemoattractant protein 1 (MCP)''' belongs to the superfamily of chemokines, which are proteins involved in immunoregulatory and inflammatory processes. The gene for CCL2 is on chromosome 17 in region 17q11.2-q12. The superfamily can be subdivided into 4 smaller groups, depending on the N-terminal arrangement of the cysteines. The CCL2<ref>PMID:8170963</ref> is also known as '''chemokine (C-C motif) ligand''' or: | ||
- | - MCP1 | ||
- small inducible cytokine A2 (SCYA2) | - small inducible cytokine A2 (SCYA2) | ||
- MCAF | - MCAF | ||
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It exists as a monomer or a dimer, even though the homodimer form is preferred. | It exists as a monomer or a dimer, even though the homodimer form is preferred. | ||
The structure of the monomer is made of <scene name='72/721520/Ligand_binding_on_ccl2/2'>3 Beta sheets and 1 alpha helix</scene>. | The structure of the monomer is made of <scene name='72/721520/Ligand_binding_on_ccl2/2'>3 Beta sheets and 1 alpha helix</scene>. | ||
*'''MCP-1''' regulates migration and infiltration of monocytes/macrophages<ref>PMID:19441883</ref>. | |||
*'''MCP-3''' activates all types of leukocytes<ref>PMID:11781181</ref>. | |||
*'''MCP-4''' is a potent chemoattractant for monocytes and eosinophils and stimulates histamine release from basophils<ref>PMID:8955214</ref>. | |||
== Ligands == | == Ligands == | ||
The known ligands for CCL2 are <scene name='72/721520/Ligand_binding_on_ccl2/1'>Potassium and PO4</scene>. The potassium binds to the S33 and S34 of the monomer and PO4 binds to F15 and N17. | The known ligands for CCL2 are <scene name='72/721520/Ligand_binding_on_ccl2/1'>Potassium and PO4</scene>. The potassium binds to the S33 and S34 of the monomer and PO4 binds to F15 and N17. | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
* Monocyte chemoattractant protein 1 | * Monocyte chemoattractant protein 1 1 or C-C motif chemokine 2 or CCL2 | ||
**[[1dok]], [[1dol]] – hMCP-1 (mutant) - human<br /> | **[[1dok]], [[1dol]] – hMCP-1 (mutant) - human<br /> | ||
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**[[4zk9]] – hMCP-1 + chemokine binding protein<br /> | **[[4zk9]] – hMCP-1 + chemokine binding protein<br /> | ||
**[[4r8i]] – hMCP-1 + RNA<br /> | **[[4r8i]] – hMCP-1 + RNA<br /> | ||
**[[7so0]], [[8fj0]] – hMCP-1 + evasin<br /> | |||
* Monocyte chemoattractant protein 2 | * Monocyte chemoattractant protein 2 or CCL8 or C-C motif chemokine 8 | ||
**[[7s5a]] – hMCP-2 <br /> | |||
**[[1esr]] – hMCP-2 (mutant) <br /> | **[[1esr]] – hMCP-2 (mutant) <br /> | ||
* Monocyte chemoattractant protein 3 | * Monocyte chemoattractant protein 3 or C-C motif chemokine 7 or CCL7 | ||
**[[1ncv]], [[1bo0]] – hMCP-3 - NMR<br /> | **[[1ncv]], [[1bo0]] – hMCP-3 - NMR<br /> | ||
**[[4zkc]] – hMCP-3 + chemokine binding protein<br /> | **[[4zkc]] – hMCP-3 + chemokine binding protein<br /> | ||
**[[7s58]], [[7s59]], [[7scu]] – hMCP-3 + evasin<br /> | |||
**[[8fk6]], [[8fk8]] – hMCP-3 + evasin<br /> | |||
**[[8fj3]] – hMCP-3 (mutant) + evasin<br /> | |||
* Monocyte chemoattractant protein 4 | * Monocyte chemoattractant protein 4 | ||
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http://www.rcsb.org/pdb/explore/explore.do?structureId=3IFD | http://www.rcsb.org/pdb/explore/explore.do?structureId=3IFD | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||