Monocyte chemoattractant protein: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Coline Perrin, Alexane Caignard, Michal Harel, Joel L. Sussman

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-<StructureSection load='1dok' size='350' side='right' caption='Monocyte chemoattractant protein 1 (PDB code [[3idf]])' scene='72/721520/Cv/2'>
+<StructureSection load='' size='350' side='right' caption='Monocyte chemoattractant protein 1 complex with sulfate (PDB code [[1dok]])' scene='72/721520/Cv/2'>
 == Function and Structure ==
-'''Human synthetic monocyte chemoattractant protein 1 (MCP)''' belongs to the superfamily of chemokines, which are proteins involved in immunoregulatory and inflammatory processes. The gene for CCL2 is on chromosome 17 in region 17q11.2-q12. The superfamily can be subdivided into 4 smaller groups, depending on the N-ter arangment of the cysteines.  The CCL2<ref>PMID:8170963</ref> is also known as '''chemokine (C-C motif) ligand''' or:
+Human synthetic '''monocyte chemoattractant protein 1 (MCP)''' belongs to the superfamily of chemokines, which are proteins involved in immunoregulatory and inflammatory processes. The gene for CCL2 is on chromosome 17 in region 17q11.2-q12. The superfamily can be subdivided into 4 smaller groups, depending on the N-terminal arrangement of the cysteines.  The CCL2<ref>PMID:8170963</ref> is also known as '''chemokine (C-C motif) ligand''' or:
 - MCP1
 - small inducible cytokine A2 (SCYA2)
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 - HC11.
-It exists as a monomer or a dimer, eventhough the homodimer form is preferred.
+It exists as a monomer or a dimer, even though the homodimer form is preferred.
+The structure of the monomer is made of <scene name='72/721520/Ligand_binding_on_ccl2/2'>3 Beta sheets and 1 alpha helix</scene>.
+*'''MCP-1''' regulates migration and infiltration of monocytes/macrophages<ref>PMID:19441883</ref>.
-<scene name='72/721520/Ligand_binding_on_ccl2/2'>Beta sheets and alpha helix on monomer</scene>
+*'''MCP-3''' activates all types of leukocytes<ref>PMID:11781181</ref>.
+*'''MCP-4''' is a potent chemoattractant for monocytes and eosinophils and stimulates histamine release from basophils<ref>PMID:8955214</ref>.
 == Ligands ==
-The known ligands for CCL2 are <scene name='72/721520/Ligand_binding_on_ccl2/1'>Potassium and PO4</scene>.
+The known ligands for CCL2 are <scene name='72/721520/Ligand_binding_on_ccl2/1'>Potassium and PO4</scene>. The potassium binds to the S33 and S34 of the monomer and PO4 binds to F15 and N17.
 == Diseases ==
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 </StructureSection>
-[[Media:proteopedia.odg]]
+[[Image:chaine.png]]
 == Synthesis ==
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 {{#tree:id=OrganizedByTopic|openlevels=0|
-* Monocyte chemoattractant protein 1
+* Monocyte chemoattractant protein 1 1 or C-C motif chemokine 2 or CCL2
 **[[1dok]], [[1dol]] – hMCP-1 (mutant) - human<br />
-**[[3ifd]] – hMCP-1 <br />
 **[[1dom]], [[1don]] – hMCP-1 - NMR<br />
 **[[1ml0]], [[2nz1]] – hMCP-1 (mutant) + M3 protein<br />
@@ Line 54: / Line 54: @@
 **[[4zk9]] – hMCP-1 + chemokine binding protein<br />
 **[[4r8i]] – hMCP-1 + RNA<br />
+**[[7so0]], [[8fj0]] – hMCP-1 + evasin<br />
-* Monocyte chemoattractant protein 2
+* Monocyte chemoattractant protein 2 or CCL8 or C-C motif chemokine 8
+**[[7s5a]] – hMCP-2 <br />
 **[[1esr]] – hMCP-2 (mutant) <br />
-* Monocyte chemoattractant protein 3
+* Monocyte chemoattractant protein 3 or C-C motif chemokine 7 or CCL7
 **[[1ncv]], [[1bo0]] – hMCP-3 - NMR<br />
 **[[4zkc]] – hMCP-3 + chemokine binding protein<br />
+**[[7s58]], [[7s59]], [[7scu]] – hMCP-3 + evasin<br />
+**[[8fk6]], [[8fk8]] – hMCP-3 + evasin<br />
+**[[8fj3]] – hMCP-3 (mutant) + evasin<br />
 * Monocyte chemoattractant protein 4
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 http://www.rcsb.org/pdb/explore/explore.do?structureId=3IFD
 <references/>
+[[Category:Topic Page]]