3jcl: Difference between revisions
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==Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer== | ==Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer== | ||
< | <SX load='3jcl' size='340' side='right' viewer='molstar' caption='[[3jcl]], [[Resolution|resolution]] 4.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3jcl]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3jcl]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_hepatitis_virus_strain_A59 Murine hepatitis virus strain A59]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JCL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JCL FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jcl OCA], [https://pdbe.org/3jcl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jcl RCSB], [https://www.ebi.ac.uk/pdbsum/3jcl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jcl ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/SPIKE_CVMA5 SPIKE_CVMA5] S1 attaches the virion to the cell membrane by interacting with murine CEACAM1, initiating the infection.<ref>PMID:16014947</ref> S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Presumably interacts with target cell lipid raft after cell attachment.<ref>PMID:16014947</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 3jcl" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3jcl" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Sandbox 3001|Sandbox 3001]] | |||
*[[Spike protein 3D structures|Spike protein 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</ | </SX> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Bosch | [[Category: Murine hepatitis virus strain A59]] | ||
[[Category: DiMaio | [[Category: Bosch BJ]] | ||
[[Category: Frenz | [[Category: DiMaio F]] | ||
[[Category: Rey | [[Category: Frenz B]] | ||
[[Category: Rottier | [[Category: Rey FA]] | ||
[[Category: Tortorici | [[Category: Rottier PJM]] | ||
[[Category: Veesler | [[Category: Tortorici MA]] | ||
[[Category: Walls | [[Category: Veesler D]] | ||
[[Category: Walls AC]] | |||