5ez0: Difference between revisions

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-'''Unreleased structure'''
-The entry 5ez0 is ON HOLD  until Paper Publication
+==CRYSTAL STRUCTURE OF THE PTPN4 PDZ DOMAIN COMPLEXED WITH THE PDZ BINDING MOTIF OF THE MITOGEN ACTIVATED PROTEIN KINASE P38GAMMA.==
+<StructureSection load='5ez0' size='340' side='right'caption='[[5ez0]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ez0]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EZ0 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ez0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ez0 OCA], [https://pdbe.org/5ez0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ez0 RCSB], [https://www.ebi.ac.uk/pdbsum/5ez0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ez0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/B5MDL5_HUMAN B5MDL5_HUMAN]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The human protein tyrosine phosphatase non-receptor type 4 (PTPN4) prevents cell death induction in neuroblastoma and glioblastoma cell lines in a PDZ-PDZ binding motifs (PBMs) dependent manner but the cellular partners of PTPN4 involved in cell protection are unknown. Here, we described the Mitogen-Activated protein kinase p38gamma as a cellular partner of PTPN4. The main contribution to the p38gamma:PTPN4 complex formation is the tight interaction between the C-terminus of p38gamma and the PDZ domain of PTPN4. We solved the crystal structure of the PDZ domain of PTPN4 bound to the p38gamma C-terminus. We identified the molecular basis of recognition of the C-terminal sequence of p38gamma that displays the highest affinity amongst all endogenous partners of PTPN4. We showed that the p38gamma C-terminus is also an efficient inducer of cell death after its intracellular delivery. In addition to recruiting the kinase, the binding of the C-terminal sequence of p38gamma to PTPN4 abolishes the catalytic auto-inhibition of PTPN4 and thus activates the phosphatase that can efficiently dephosphorylate the activation loop of p38gamma. We presume that the p38gamma-PTPN4 interaction promotes cellular signaling preventing cell death induction.
-Authors: MAISONNEUVE, P., VANEY, M.C., CAILLET-SAGUY, C., LAFON, M., DELEPIERRE, M., CORDIER, F., WOLFF, N.
+Molecular Basis of The Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-Activated Protein Kinase p38gamma.,Maisonneuve P, Caillet-Saguy C, Vaney MC, Edoo BZ, Sawyer K, Raynal B, Delepierre M, Lafon M, Cordier F, Wolff N J Biol Chem. 2016 May 31. pii: jbc.M115.707208. PMID:27246854<ref>PMID:27246854</ref>
-Description: CRYSTAL STRUCTURE OF THE PTPN4 PDZ DOMAIN COMPLEXED WITH THE PDZ BINDING MOTIF OF THE MITOGEN ACTIVATED PROTEIN KINASE P38GAMMA.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Caillet-Saguy, C]]
+<div class="pdbe-citations 5ez0" style="background-color:#fffaf0;"></div>
-[[Category: Vaney, M.C]]
-[[Category: Lafon, M]]
+==See Also==
-[[Category: Delepierre, M]]
+*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
-[[Category: Cordier, F]]
+== References ==
-[[Category: Maisonneuve, P]]
+<references/>
-[[Category: Wolff, N]]
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Caillet-Saguy C]]
+[[Category: Cordier F]]
+[[Category: Delepierre M]]
+[[Category: Lafon M]]
+[[Category: Maisonneuve P]]
+[[Category: Vaney MC]]
+[[Category: Wolff N]]