2n99: Difference between revisions

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OCA

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 ==Solution structure of the SLURP-2, a secreted isoform of Lynx1==
-<StructureSection load='2n99' size='340' side='right' caption='[[2n99]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='2n99' size='340' side='right'caption='[[2n99]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2n99]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N99 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N99 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2n99]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N99 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n99 OCA], [http://pdbe.org/2n99 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n99 RCSB], [http://www.ebi.ac.uk/pdbsum/2n99 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n99 ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n99 OCA], [https://pdbe.org/2n99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n99 RCSB], [https://www.ebi.ac.uk/pdbsum/2n99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n99 ProSAT]</span></td></tr>
 </table>
-== Function ==
-[[http://www.uniprot.org/uniprot/LYNX1_HUMAN LYNX1_HUMAN]] Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). In brain, isoform 2 modulates functional properties of nAChRs to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha(4)beta(2) nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha(4)beta(2) nAChRs (By similarity). Prevents plasticity in the primary visual cortex late in life (By similarity). In keratinocytes, isoform 3 delays differentiation and prevents apoptosis.<ref>PMID:16575903</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 20: @@
 __TOC__
 </StructureSection>
-[[Category: Arseniev, A S]]
+[[Category: Homo sapiens]]
-[[Category: Lyukmanova, E N]]
+[[Category: Large Structures]]
-[[Category: Paramonov, A S]]
+[[Category: Arseniev AS]]
-[[Category: Shenkarev, Z O]]
+[[Category: Lyukmanova EN]]
-[[Category: Cell proliferation]]
+[[Category: Paramonov AS]]
-[[Category: Epithelium]]
+[[Category: Shenkarev ZO]]
-[[Category: Keratinocyte]]
-[[Category: Muscarinic acetylcholine receptor]]
-[[Category: Neuromodulator]]
-[[Category: Neuropeptide]]
-[[Category: Nicotinic acetylcholine receptor]]
-[[Category: Three-finger protein]]