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Cyclin-dependent kinase regulatory subunit: Difference between revisions

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== Function ==
== Function ==


'''Cyclin-dependent kinase regulatory subunit''' (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex.  CKS binds to the catalytic subunit of CDK see complex structure in <scene name='71/715441/Pdb4yc6/1'>pdb 4yc6</scene> where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red.  CKS1 is essential for CDK5 functioning in neuronal differentiation.<ref>PMID:8491379</ref>   
'''Cyclin-dependent kinase regulatory subunit''' (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex.  CKS binds to the catalytic subunit of CDK see complex structure in <scene name='71/715441/Pdb4yc6/1'>pdb 4yc6</scene> where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red.   
*'''CKS1''' is essential for CDK5 functioning in neuronal differentiation.<ref>PMID:8491379</ref>   
*'''CKS2''' is implicated as an oncogene in various malignancies.<ref>PMID:31781310</ref>


== Structural highlights ==
== Structural highlights ==
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CKS exists as hexamer of homodimers and can bind six kinase molecules.
CKS exists as hexamer of homodimers and can bind six kinase molecules.


</StructureSection>
== 3D Structures of cyclin-dependent kinase regulatory subunit ==
== 3D Structures of cyclin-dependent kinase regulatory subunit ==
[[Cyclin-dependent kinase regulatory subunit 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*CKS
 
**[[4lpa]], [[1qb3]] – yCKS 1 - yeast<br />
**[[3qy2]] – yCKS 1 (mutant)<br />
**[[1puc]], [[1sce]] – fyCKS 1 – fission yeast<br />
**[[1dks]], [[1dkt]] – hCKS 1 - human<br />
**[[1cks]] – hCKS 2<br />
 
*CKS complexes


**[[4yc6]] – hCKS 1 + CDK1 <br />
**[[1buh]] – hCKS 1 + CDK2<br />
**[[1h4l]], [[1ung]] – hCKS 1 + CDK5<br />
**[[1unh]], [[1unl]] – hCKS 1 + CDK5 + inhibitor<br />
**[[3o0g]] – hCKS 1 + CDK5 + ATP analog<br />
**[[2ass]] – hCKS 1 + Skp1 + Skp2<br />
**[[2ast]] – hCKS 1 + Skp1 + Skp2 + CDK inhibitor peptide<br />
**[[4y72]], [[4yc3]], [[5hq0]], [[5lqf]] – hCKS 2 + cyclin B1 + CDK1<br />
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

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Michal Harel, Alexander Berchansky
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