Cyclin-dependent kinase regulatory subunit: Difference between revisions

Latest revision as of 13:16, 9 June 2024

Function

Cyclin-dependent kinase regulatory subunit (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex. CKS binds to the catalytic subunit of CDK see complex structure in where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red.

CKS1 is essential for CDK5 functioning in neuronal differentiation.^[1]
CKS2 is implicated as an oncogene in various malignancies.^[2]

Structural highlights

CKS exists as hexamer of homodimers and can bind six kinase molecules.

3D Structures of cyclin-dependent kinase regulatory subunit

Cyclin-dependent kinase regulatory subunit 3D structures

ReferencesReferences

↑ Tang Y, Reed SI. The Cdk-associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae. Genes Dev. 1993 May;7(5):822-32. PMID:8491379
↑ Zhang J, Song Q, Liu J, Lu L, Xu Y, Zheng W. Cyclin-Dependent Kinase Regulatory Subunit 2 Indicated Poor Prognosis and Facilitated Aggressive Phenotype of Hepatocellular Carcinoma. Dis Markers. 2019 Oct 22;2019:8964015. PMID:31781310 doi:10.1155/2019/8964015

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Michal Harel, Alexander Berchansky

[1] Tang Y, Reed SI. The Cdk-associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae. Genes Dev. 1993 May;7(5):822-32. PMID:8491379

[2] Zhang J, Song Q, Liu J, Lu L, Xu Y, Zheng W. Cyclin-Dependent Kinase Regulatory Subunit 2 Indicated Poor Prognosis and Facilitated Aggressive Phenotype of Hepatocellular Carcinoma. Dis Markers. 2019 Oct 22;2019:8964015. PMID:31781310 doi:10.1155/2019/8964015

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[2]

@@ Line 2: / Line 2: @@
 == Function ==
-'''Cyclin-dependent kinase regulatory subunit''' (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex.  CKS binds to the catalytic subunit of CDK see complex structure in <scene name='71/715441/Pdb4yc6/1'>pdb 4yc6</scene> where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red.  CKS1 is essential for CDK5 functioning in neuronal differentiation.<ref>PMID:8491379</ref>
+'''Cyclin-dependent kinase regulatory subunit''' (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex.  CKS binds to the catalytic subunit of CDK see complex structure in <scene name='71/715441/Pdb4yc6/1'>pdb 4yc6</scene> where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red.
+*'''CKS1''' is essential for CDK5 functioning in neuronal differentiation.<ref>PMID:8491379</ref>
-== Disease ==
+*'''CKS2''' is implicated as an oncogene in various malignancies.<ref>PMID:31781310</ref>
-== Relevance ==
 == Structural highlights ==
@@ Line 12: / Line 10: @@
 CKS exists as hexamer of homodimers and can bind six kinase molecules.
-</StructureSection>
 == 3D Structures of cyclin-dependent kinase regulatory subunit ==
+[[Cyclin-dependent kinase regulatory subunit 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*CKS
-**[[4lpa]], [[1qb3]] – yCKS 1 - yeast<br />
-**[[3qy2]] – yCKS 1 (mutant)<br />
-**[[1puc]], [[1sce]] – fyCKS 1 – fission yeast<br />
-**[[1dks]], [[1dkt]] – hCKS 1 - human<br />
-**[[1cks]] – hCKS 2<br />
-*CKS complexes
-**[[4yc6]] – hCKS 1 + CDK1 <br />
-**[[1buh]] – hCKS 1 + CDK2<br />
-**[[1h4l]], [[1ung]] – hCKS 1 + CDK5<br />
-**[[1unh]], [[1unl]] – hCKS 1 + CDK5 + inhibitor<br />
-**[[3o0g]] – hCKS 1 + CDK5 + ATP analog<br />
-**[[2ass]] – hCKS 1 + Skp1 + Skp2<br />
-**[[2ast]] – hCKS 1 + Skp1 + Skp2 + CDK inhibitor peptide<br />
-**[[4y72]] – hCKS 2 + cyclin B1 + CDK1<br />
-}}
 == References ==
 <references/>
+[[Category:Topic Page]]