Cyclin-dependent kinase regulatory subunit: Difference between revisions

Latest revision as of 13:16, 9 June 2024

Function

Cyclin-dependent kinase regulatory subunit (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex. CKS binds to the catalytic subunit of CDK see complex structure in where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red.

CKS1 is essential for CDK5 functioning in neuronal differentiation.^[1]
CKS2 is implicated as an oncogene in various malignancies.^[2]

Structural highlights

CKS exists as hexamer of homodimers and can bind six kinase molecules.

3D Structures of cyclin-dependent kinase regulatory subunit

Cyclin-dependent kinase regulatory subunit 3D structures

ReferencesReferences

↑ Tang Y, Reed SI. The Cdk-associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae. Genes Dev. 1993 May;7(5):822-32. PMID:8491379
↑ Zhang J, Song Q, Liu J, Lu L, Xu Y, Zheng W. Cyclin-Dependent Kinase Regulatory Subunit 2 Indicated Poor Prognosis and Facilitated Aggressive Phenotype of Hepatocellular Carcinoma. Dis Markers. 2019 Oct 22;2019:8964015. PMID:31781310 doi:10.1155/2019/8964015

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Michal Harel, Alexander Berchansky

[1] Tang Y, Reed SI. The Cdk-associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae. Genes Dev. 1993 May;7(5):822-32. PMID:8491379

[2] Zhang J, Song Q, Liu J, Lu L, Xu Y, Zheng W. Cyclin-Dependent Kinase Regulatory Subunit 2 Indicated Poor Prognosis and Facilitated Aggressive Phenotype of Hepatocellular Carcinoma. Dis Markers. 2019 Oct 22;2019:8964015. PMID:31781310 doi:10.1155/2019/8964015

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[2]

@@ Line 1: / Line 1: @@
-<StructureSection load='4yc6' size='340' side='right' caption='4yc6, resolution 2.60Å)' scene=''>
+<StructureSection load='1dks' size='340' side='right' caption='Human CKS-1 complex with phosphate (PDB code [[1dks]])' scene=''>
-'''Cyclin-dependent kinase regulatory subunit''' (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex.  CKS binds to the catalytic subunit of CDK see complex structure in the figure at top left.  CKS1 is essential for CDK5 functioning in neuronal diferentiation.  CKS exists as hexamer of homodimers and can bind six kinase molecules.
 == Function ==
-== Disease ==
+'''Cyclin-dependent kinase regulatory subunit''' (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex.  CKS binds to the catalytic subunit of CDK see complex structure in <scene name='71/715441/Pdb4yc6/1'>pdb 4yc6</scene> where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red.
+*'''CKS1''' is essential for CDK5 functioning in neuronal differentiation.<ref>PMID:8491379</ref>
+*'''CKS2''' is implicated as an oncogene in various malignancies.<ref>PMID:31781310</ref>
-== Relevance ==
+== Structural highlights ==
-== Structural highlights ==
+CKS exists as hexamer of homodimers and can bind six kinase molecules.
-</StructureSection>
 == 3D Structures of cyclin-dependent kinase regulatory subunit ==
+[[Cyclin-dependent kinase regulatory subunit 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*CKS
-**[[4lpa]], [[1qb3]] – yCKS 1 - yeast<br />
-**[[3qy2]] – yCKS 1 (mutant)<br />
-**[[1puc]], [[1sce]] – fyCKS 1 – fission yeast<br />
-**[[1dks]], [[1dkt]] – hCKS 1 - human<br />
-**[[1cks]] – hCKS 2<br />
-*CKS complexes
-**[[4yc6]] – hCKS 1 + CDK1 <br />
-**[[1buh]] – hCKS 1 + CDK2<br />
-**[[1h4l]], [[1ung]] – hCKS 1 + CDK5<br />
-**[[1unh]], [[1unl]] – hCKS 1 + CDK5 + inhibitor<br />
-**[[3o0g]] – hCKS 1 + CDK5 + ATP analog<br />
-**[[2ass]] – hCKS 1 + Skp1 + Skp2<br />
-**[[2ast]] – hCKS 1 + Skp1 + Skp2 + CDK inhibitor peptide<br />
-**[[4y72]] – hCKS 2 + cyclin B1 + CDK1<br />
-}}
 == References ==
 <references/>
+[[Category:Topic Page]]