5d13: Difference between revisions

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==Third PDZ domain (PDZ3) of PSD-95 complexed with CFMOC-KKETEV peptide==
==Third PDZ domain (PDZ3) of PSD-95 complexed with CFMOC-KKETEV peptide==
<StructureSection load='5d13' size='340' side='right' caption='[[5d13]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='5d13' size='340' side='right'caption='[[5d13]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5d13]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D13 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5d13]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D13 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=56J:3-(9H-FLUOREN-9-YL)PROPANAL'>56J</scene>, <scene name='pdbligand=LYS:LYSINE'>LYS</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.151&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d13 OCA], [http://pdbe.org/5d13 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d13 RCSB], [http://www.ebi.ac.uk/pdbsum/5d13 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d13 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=56J:3-(9H-FLUOREN-9-YL)PROPANAL'>56J</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d13 OCA], [https://pdbe.org/5d13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d13 RCSB], [https://www.ebi.ac.uk/pdbsum/5d13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d13 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>
[https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>  
 
==See Also==
*[[Postsynaptic density protein 3D structures|Postsynaptic density protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: De, S]]
[[Category: Large Structures]]
[[Category: Olson, R]]
[[Category: Rattus norvegicus]]
[[Category: Spaller, M R]]
[[Category: Synthetic construct]]
[[Category: Protein-peptide complex]]
[[Category: De S]]
[[Category: Signaling protein-inhibitor complex]]
[[Category: Olson R]]
[[Category: Spaller MR]]

Latest revision as of 11:51, 14 July 2024

Third PDZ domain (PDZ3) of PSD-95 complexed with CFMOC-KKETEV peptideThird PDZ domain (PDZ3) of PSD-95 complexed with CFMOC-KKETEV peptide

Structural highlights

5d13 is a 9 chain structure with sequence from Rattus norvegicus and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.151Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DLG4_RAT Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.[1] [2]

See Also

References

  1. ↑ Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ. PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. J Biol Chem. 2004 Nov 5;279(45):46962-8. Epub 2004 Aug 17. PMID:15317815 doi:10.1074/jbc.M405874200
  2. ↑ Prange O, Wong TP, Gerrow K, Wang YT, El-Husseini A. A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin. Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13915-20. Epub 2004 Sep 9. PMID:15358863 doi:10.1073/pnas.0405939101

5d13, resolution 2.15Å

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