5crf: Difference between revisions
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==Structure of the penicillin-binding protein PonA1 from Mycobacterium Tuberculosis== | ==Structure of the penicillin-binding protein PonA1 from Mycobacterium Tuberculosis== | ||
<StructureSection load='5crf' size='340' side='right' caption='[[5crf]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='5crf' size='340' side='right'caption='[[5crf]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5crf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CRF OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5crf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CRF FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5crf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5crf OCA], [https://pdbe.org/5crf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5crf RCSB], [https://www.ebi.ac.uk/pdbsum/5crf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5crf ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PBP1A_MYCTU PBP1A_MYCTU] Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (By similarity). Has little peptidoglycan hydrolytic activity; however it inhibits the synergistic peptidoglycan hydrolysis of RipA plus RpfB.<ref>PMID:20686708</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5crf" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5crf" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
[[Category: | [[Category: Anderson WF]] | ||
[[Category: | [[Category: Endres M]] | ||
[[Category: | [[Category: Filippova EV]] | ||
[[Category: | [[Category: Joachimiak A]] | ||
[[Category: | [[Category: Kieser K]] | ||
[[Category: | [[Category: Kiryukhina O]] | ||
[[Category: Rubin | [[Category: Rubin E]] | ||
[[Category: Sacchettini | [[Category: Sacchettini J]] | ||
[[Category: Wawrzak | [[Category: Wawrzak Z]] | ||