Rho guanine nucleotide exchange factor: Difference between revisions
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<StructureSection load='3kz1' size='340' side='right' caption='Human Rho guanine nucleotide exchange factor 11 DH/PH domain (grey) complex with transforming protein RhoA (cyan), GSP and Mg+2 ion (green) (PDB code [[3kz1]])' scene=''> | <StructureSection load='3kz1' size='340' side='right' caption='Human Rho guanine nucleotide exchange factor 11 DH/PH domain (grey) complex with transforming protein RhoA (cyan), GSP and Mg+2 ion (green) (PDB code [[3kz1]])' scene=''> | ||
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== Function == | == Function == | ||
'''Rho guanine nucleotide exchange factor''' (GEF) stimulate the exchange of the inactive GDP-bound GTPase to its active GTP-bound form. Binding of GEF to GDP-GTPase catalyzes the dissociation of GDP from the protein<ref>PMID:23303910</ref>. GEF domains include the catalytic DH/PH (Dbl Homology/Pleckstrin Homology) domain; the CH (Calponin Homology) domain is believed to be involved in calcium regulation; the SH3 domain interacts with proline-rich sequences. | '''Rho guanine nucleotide exchange factor''' (GEF) stimulate the exchange of the inactive GDP-bound GTPase to its active GTP-bound form. Binding of GEF to GDP-GTPase catalyzes the dissociation of GDP from the protein<ref>PMID:23303910</ref>. GEF domains include the catalytic DH/PH (Dbl Homology/Pleckstrin Homology) domain; the CH (Calponin Homology) domain is believed to be involved in calcium regulation; the SH3 domain interacts with proline-rich sequences. | ||
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*'''Rho guanine nucleotide exchange factor 6''' and '''Rho guanine nucleotide exchange factor 7''' act on Rac1.<br /> | *'''Rho guanine nucleotide exchange factor 6''' and '''Rho guanine nucleotide exchange factor 7''' act on Rac1.<br /> | ||
*'''Rho guanine nucleotide exchange factor 9''' mutations involved in developmental and epileptic encephalopathy<ref>PMID:35638461</ref>. | *'''Rho guanine nucleotide exchange factor 9''' mutations involved in developmental and epileptic encephalopathy<ref>PMID:35638461</ref>. | ||
*'''Rho guanine nucleotide exchange factor 11''' mediates Rho-myosin light chain signaling pathways at cell-cell junctions<ref>PMID:22665792</ref>. | |||
*'''Rho guanine nucleotide exchange factor 18''' regulates tissue architecture and function via RhoA activation<ref>PMID:23698346</ref>. | |||
*'''Rho guanine nucleotide exchange factor 25''' involved in contraction of vascular smooth muscle. | |||
== Disease == | == Disease == | ||