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Rho guanine nucleotide exchange factor: Difference between revisions

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<StructureSection load='3kz1' size='340' side='right' caption='Human Rho guanine nucleotide exchange factor 11 DH/PH domain (grey) complex with  transforming protein RhoA (cyan), GSP and Mg+2 ion (green) (PDB code [[3kz1]])' scene=''>
<StructureSection load='3kz1' size='340' side='right' caption='Human Rho guanine nucleotide exchange factor 11 DH/PH domain (grey) complex with  transforming protein RhoA (cyan), GSP and Mg+2 ion (green) (PDB code [[3kz1]])' scene=''>
__TOC__
== Function ==
== Function ==
'''Rho guanine nucleotide exchange factor''' (GEF) stimulate the exchange of the inactive GDP-bound GTPase to its active GTP-bound form.  Binding of GEF to GDP-GTPase catalyzes the dissociation of GDP from the protein<ref>PMID:23303910</ref>.  GEF domains include the catalytic DH/PH (Dbl Homology/Pleckstrin Homology) domain; the CH (Calponin Homology) domain is believed to be involved in calcium regulation; the SH3 domain interacts with proline-rich sequences.
'''Rho guanine nucleotide exchange factor''' (GEF) stimulate the exchange of the inactive GDP-bound GTPase to its active GTP-bound form.  Binding of GEF to GDP-GTPase catalyzes the dissociation of GDP from the protein<ref>PMID:23303910</ref>.  GEF domains include the catalytic DH/PH (Dbl Homology/Pleckstrin Homology) domain; the CH (Calponin Homology) domain is believed to be involved in calcium regulation; the SH3 domain interacts with proline-rich sequences.


*'''Rho guanine nucleotide exchange factor 1''' binds to G proteins and stimulate Rho-dependent signals.<br />
*'''Rho guanine nucleotide exchange factor 1''' binds to G proteins and stimulate Rho-dependent signals.<br />
*'''Rho guanine nucleotide exchange factor 6''' acts on RAC1.<br />
*'''Rho guanine nucleotide exchange factor 3''' acts on RHOA and RHOB involved in bone biology.<br />
*'''Rho guanine nucleotide exchange factor 6''' and '''Rho guanine nucleotide exchange factor 7''' act on Rac1.<br />
*'''Rho guanine nucleotide exchange factor 9''' mutations involved in developmental and epileptic encephalopathy<ref>PMID:35638461</ref>.
*'''Rho guanine nucleotide exchange factor 11''' mediates Rho-myosin light chain signaling pathways at cell-cell junctions<ref>PMID:22665792</ref>.
*'''Rho guanine nucleotide exchange factor 18''' regulates tissue architecture and function via RhoA activation<ref>PMID:23698346</ref>.
*'''Rho guanine nucleotide exchange factor 25''' involved in contraction of vascular smooth muscle.


== Disease ==
== Disease ==
Increased GEF activity is involved in cancer cell proliferation by affecting Rho GTPases <ref>PMID:24037532</ref>.
Increased GEF activity is involved in cancer cell proliferation by affecting Rho GTPases <ref>PMID:24037532</ref>.
== 3D Structures of Rho guanine nucleotide exchange factor ==
[[Rho guanine nucleotide exchange factor 3D structures]]


</StructureSection>
</StructureSection>


== 3D Structures of Rho guanine nucleotide exchange factor ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Rho guanine nucleotide exchange factor 1 (P115-RhoGEF)
**[[1iap]] – hGEF N terminal - human<br />
**[[3odo]], [[3odw]], [[3odx]] – hGEF DH/PH domain <br />
**[[3p6a]] – hGEF DH/PH domain (mutant)<br />
**[[1shz]], [[3ab3]] – hGEF N terminal + guanine nucleotide-binding protein<br />
*Rho guanine nucleotide exchange factor 2
**[[5efx]] - hGEF residues 439-582<br />
*Rho guanine nucleotide exchange factor 4 (Asef)
**[[2dx1]], [[2pz1]] – hGEF <br />
**[[3nmx]], [[3nmz]] – hGEF + APC variant protein<br />
*Rho guanine nucleotide exchange factor 6
**[[1ujy]] – hGEF SH3 domain - NMR<br />
**[[1wyr]] – hGEF CH domain - NMR<br />
*Rho guanine nucleotide exchange factor 7 (β-PIX)
**[[1by1]] – hGEF DH domain - NMR<br />
**[[2l3g]] – hGEF CH domain - NMR<br />
**[[2esw]] – GEF SH3 domain – mouse<br />
**[[2g6f]] – rGEF SH3 domain – rat<br />
**[[2w6b]] – rGEF coiled-coil domain  <br />
*Rho guanine nucleotide exchange factor 7 complex with peptide
**[[2ak5]] – hGEF SH3 domain + CBL-b peptide <br />
**[[2df6]] – hGEF SH3 domain + PAK-1 peptide <br />
**[[1zsg]] – hGEF residues 179-243 + PAK-1 peptide – NMR<br />
**[[5sxp]] - hGEF residues 183-243 + E3 ubiquitin-protein ligase itchy<br />
**[[2p4r]] – rGEF SH3 domain + E3 ubiquitin protein ligase peptide <br />
**[[3l4f]] – rGEF coiled-coil domain + SHANK1 PDZ domain <br />
*Rho guanine nucleotide exchange factor 8 (PRONE8)
**[[2ntx]] – AtGEF PRONE domain – ''Arabidopasis thaliana''<br />
**[[2wbl]] – AtGEF PRONE domain + GTPase ROP7 <br />
**[[2nty]] – AtGEF PRONE domain + GTPase ROP4 + GDP <br />
**[[3eo2]] – hGEF residues 161-373 <br />
**[[4xh9]] – hGEF DH/PH domain + transforming protein RhoA <br />
*Rho guanine nucleotide exchange factor 9 (collybistin)
**[[2ysq]] – hGEF SH3 domain - NMR<br />
**[[4mt6]], [[4mt7]] – rGEF (mutant)<br />
**[[2dfk]] – rGEF + CDC42 <br />
*Rho guanine nucleotide exchange factor 11
**[[2dls]] – hGEF PDZ domain - NMR<br />
**[[5tyt]] - hGEF PDZ domain/CXCR2 peptide<br />
**[[3kz1]], [[3t06]], [[5jhg]], [[5jhh]] – hGEF DH/PH domain + transforming protein RhoA <br />
**[[1xcg]] – hGEF DH/PH domain + transforming protein RhoA - NMR<br />
**[[3cx6]] – rGEF RGS domain + guanine nucleotide-binding protein <br />
**[[5e6p]] - mGEF PDZ domain + plexin-B2<br />
*Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)
**[[1txd]] – hGEF DH/PH domain <br />
**[[2omj]] – hGEF PDZ domain <br />
**[[1x86]] – hGEF DH/PH domain (mutant) + transforming protein RhoA <br />
**[[2os6]] – hGEF PDZ domain + plexin peptide – NMR<br />
*Rho guanine nucleotide exchange factor 16
**[[1x6b]] – hGEF SH3 domain - NMR<br />
*GEF guanine nucleotide exchange factor 18
**[[6bcb]] – mGEF + transforming protein RhoA<br />
*GEF guanine nucleotide exchange factor 28
**[[6bc1]] – hGEF + Ras-related C3 botulinum toxin substrate 1<br />
**[[6bc0]] – hGEF + transforming protein RhoA<br />
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

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Michal Harel, Joel L. Sussman
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