4zfg: Difference between revisions

<StructureSection load='4zfg' size='340' side='right'caption='[[4zfg]], [[Resolution|resolution]] 2.27&Aring;' scene=''>

<table><tr><td colspan='2'>[[4zfg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZFG FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfg OCA], [https://pdbe.org/4zfg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zfg RCSB], [https://www.ebi.ac.uk/pdbsum/4zfg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfg ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/ANGP2_HUMAN ANGP2_HUMAN] Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.<ref>PMID:9204896</ref> <ref>PMID:15284220</ref> <ref>PMID:19116766</ref> <ref>PMID:19223473</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Harris SF]]

[[Category: Wu P]]