5ajq: Difference between revisions

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-'''Unreleased structure'''
-The entry 5ajq is ON HOLD
+==Human LOK (STK10) in complex with Bosutinib==
+<StructureSection load='5ajq' size='340' side='right'caption='[[5ajq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ajq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AJQ FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DB8:4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYLPIPERAZIN-1-YL)PROPOXY]QUINOLINE-3-CARBONITRILE'>DB8</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ajq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ajq OCA], [https://pdbe.org/5ajq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ajq RCSB], [https://www.ebi.ac.uk/pdbsum/5ajq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ajq ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN] The disease may be caused by mutations affecting the gene represented in this entry.<ref>PMID:16175573</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN] Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.<ref>PMID:11903060</ref> <ref>PMID:12639966</ref> <ref>PMID:19255442</ref>
-Authors: Elkins, J.M., Salah, E., Krojer, T., Kopec, J., Bountra, C., Edwards, A.M., Knapp, S.
+==See Also==
+*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
-Description: Human LOK (STK10) in complex with Bosutinib
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Elkins, J.M]]
+__TOC__
-[[Category: Knapp, S]]
+</StructureSection>
-[[Category: Krojer, T]]
+[[Category: Homo sapiens]]
-[[Category: Bountra, C]]
+[[Category: Large Structures]]
-[[Category: Kopec, J]]
+[[Category: Bountra C]]
-[[Category: Edwards, A.M]]
+[[Category: Edwards AM]]
-[[Category: Salah, E]]
+[[Category: Elkins JM]]
+[[Category: Knapp S]]
+[[Category: Kopec J]]
+[[Category: Krojer T]]
+[[Category: Pinkas DM]]
+[[Category: Salah E]]