5ahv: Difference between revisions

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==Cryo-EM structure of helical ANTH and ENTH tubules on PI(4,5)P2-containing membranes==
==Cryo-EM structure of helical ANTH and ENTH tubules on PI(4,5)P2-containing membranes==
<StructureSection load='5ahv' size='340' side='right' caption='[[5ahv]], [[Resolution|resolution]] 13.60&Aring;' scene=''>
<SX load='5ahv' size='340' side='right' viewer='molstar' caption='[[5ahv]], [[Resolution|resolution]] 13.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ahv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AHV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AHV FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ahv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AHV FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ahv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ahv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ahv RCSB], [http://www.ebi.ac.uk/pdbsum/5ahv PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 13.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ahv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ahv OCA], [https://pdbe.org/5ahv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ahv RCSB], [https://www.ebi.ac.uk/pdbsum/5ahv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ahv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ENT1_YEAST ENT1_YEAST]] Binds to membranes enriched in phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Required for endocytosis and localization of actin. Negatively regulated via phosphorylation.<ref>PMID:10449404</ref> <ref>PMID:11694597</ref> <ref>PMID:12529323</ref> [[http://www.uniprot.org/uniprot/SLA2_YEAST SLA2_YEAST]] Required for cellular morphogenesis and polarization of the cortical cytoskeleton. It might act in concert with proteins such as CDC42 and CDC43 to limit the region of cortical patch formation to the cortex of the bud. Required for the accumulation and/or maintenance of plasma membrane H(+)-ATPase on the cell surface.
[https://www.uniprot.org/uniprot/ENT1_YEAST ENT1_YEAST] Binds to membranes enriched in phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Required for endocytosis and localization of actin. Negatively regulated via phosphorylation.<ref>PMID:10449404</ref> <ref>PMID:11694597</ref> <ref>PMID:12529323</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 5ahv" style="background-color:#fffaf0;"></div>
==See Also==
*[[Epsin|Epsin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Abella, M]]
[[Category: Large Structures]]
[[Category: Briggs, J A.G]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Desfosses, A]]
[[Category: Abella M]]
[[Category: Dodonova, S O]]
[[Category: Briggs JAG]]
[[Category: Gieras, A]]
[[Category: Desfosses A]]
[[Category: Hagen, W J.H]]
[[Category: Dodonova SO]]
[[Category: Jakobi, A J]]
[[Category: Gieras A]]
[[Category: Kaksonen, M]]
[[Category: Hagen WJH]]
[[Category: Meijers, R]]
[[Category: Jakobi AJ]]
[[Category: Prinz, S]]
[[Category: Kaksonen M]]
[[Category: Rybin, V]]
[[Category: Meijers R]]
[[Category: Sachse, C]]
[[Category: Prinz S]]
[[Category: Schulz, J]]
[[Category: Rybin V]]
[[Category: Skruzny, M]]
[[Category: Sachse C]]
[[Category: Uetrecht, C]]
[[Category: Schulz J]]
[[Category: Clathrin adaptor]]
[[Category: Skruzny M]]
[[Category: Clathrin binding protein]]
[[Category: Uetrecht C]]
[[Category: Clathrin-binding protein]]
[[Category: Endocytosis]]
[[Category: Enth]]
[[Category: Epsin]]
[[Category: Hip1r]]

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