4y4h: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4y4h]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y4H FirstGlance]. <br>
<table><tr><td colspan='2'>[[4y4h]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y4H FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=49X:(1R)-1,5-ANHYDRO-1-{(1E,3S,4S,5R)-4,5-DIHYDROXY-3-[(8-PHENYLOCTANOYL)AMINO]NONADEC-1-EN-1-YL}-D-GALACTITOL'>49X</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=49X:(1R)-1,5-ANHYDRO-1-{(1E,3S,4S,5R)-4,5-DIHYDROXY-3-[(8-PHENYLOCTANOYL)AMINO]NONADEC-1-EN-1-YL}-D-GALACTITOL'>49X</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y4h OCA], [https://pdbe.org/4y4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y4h RCSB], [https://www.ebi.ac.uk/pdbsum/4y4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y4h ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y4h OCA], [https://pdbe.org/4y4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y4h RCSB], [https://www.ebi.ac.uk/pdbsum/4y4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y4h ProSAT]</span></td></tr>
</table>
</table>

Latest revision as of 11:37, 23 October 2024

Crystal structure of the mCD1d/GCK152/iNKTCR ternary complexCrystal structure of the mCD1d/GCK152/iNKTCR ternary complex

Structural highlights

4y4h is a 8 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.1Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CD1D1_MOUSE Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.[1] [2] [3]

See Also

References

  1. ↑ Jayawardena-Wolf J, Benlagha K, Chiu YH, Mehr R, Bendelac A. CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity. 2001 Dec;15(6):897-908. PMID:11754812
  2. ↑ Zajonc DM, Maricic I, Wu D, Halder R, Roy K, Wong CH, Kumar V, Wilson IA. Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity. J Exp Med. 2005 Dec 5;202(11):1517-26. Epub 2005 Nov 28. PMID:16314439 doi:10.1084/jem.20051625
  3. ↑ Zajonc DM, Cantu C 3rd, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat Immunol. 2005 Aug;6(8):810-8. Epub 2005 Jul 10. PMID:16007091 doi:10.1038/ni1224

4y4h, resolution 3.10Å

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