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==Crystal structure of the mCD1d/GCK152/iNKTCR ternary complex==
==Crystal structure of the mCD1d/GCK152/iNKTCR ternary complex==
<StructureSection load='4y4h' size='340' side='right' caption='[[4y4h]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<StructureSection load='4y4h' size='340' side='right'caption='[[4y4h]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4y4h]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y4H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y4H FirstGlance]. <br>
<table><tr><td colspan='2'>[[4y4h]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y4H FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=49X:(1R)-1,5-ANHYDRO-1-{(1E,3S,4S,5R)-4,5-DIHYDROXY-3-[(8-PHENYLOCTANOYL)AMINO]NONADEC-1-EN-1-YL}-D-GALACTITOL'>49X</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4y4f|4y4f]], [[4y16|4y16]], [[4y2d|4y2d]], [[4y4k|4y4k]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=49X:(1R)-1,5-ANHYDRO-1-{(1E,3S,4S,5R)-4,5-DIHYDROXY-3-[(8-PHENYLOCTANOYL)AMINO]NONADEC-1-EN-1-YL}-D-GALACTITOL'>49X</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y4h OCA], [http://pdbe.org/4y4h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y4h RCSB], [http://www.ebi.ac.uk/pdbsum/4y4h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y4h ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y4h OCA], [https://pdbe.org/4y4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y4h RCSB], [https://www.ebi.ac.uk/pdbsum/4y4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y4h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CD1D1_MOUSE CD1D1_MOUSE]] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11754812</ref> <ref>PMID:16314439</ref> <ref>PMID:16007091</ref> [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
[https://www.uniprot.org/uniprot/CD1D1_MOUSE CD1D1_MOUSE] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11754812</ref> <ref>PMID:16314439</ref> <ref>PMID:16007091</ref>  


==See Also==
==See Also==
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
*[[T-cell receptor|T-cell receptor]]
*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Yu, E D]]
[[Category: Homo sapiens]]
[[Category: Zajonc, D M]]
[[Category: Large Structures]]
[[Category: Glycolipid antigen presentation]]
[[Category: Mus musculus]]
[[Category: Ig-fold]]
[[Category: Yu ED]]
[[Category: Immune system]]
[[Category: Zajonc DM]]
[[Category: Mhc-fold]]
[[Category: T cell receptor]]

Latest revision as of 11:37, 23 October 2024

Crystal structure of the mCD1d/GCK152/iNKTCR ternary complexCrystal structure of the mCD1d/GCK152/iNKTCR ternary complex

Structural highlights

4y4h is a 8 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.1Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CD1D1_MOUSE Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.[1] [2] [3]

See Also

References

  1. ↑ Jayawardena-Wolf J, Benlagha K, Chiu YH, Mehr R, Bendelac A. CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity. 2001 Dec;15(6):897-908. PMID:11754812
  2. ↑ Zajonc DM, Maricic I, Wu D, Halder R, Roy K, Wong CH, Kumar V, Wilson IA. Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity. J Exp Med. 2005 Dec 5;202(11):1517-26. Epub 2005 Nov 28. PMID:16314439 doi:10.1084/jem.20051625
  3. ↑ Zajonc DM, Cantu C 3rd, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat Immunol. 2005 Aug;6(8):810-8. Epub 2005 Jul 10. PMID:16007091 doi:10.1038/ni1224

4y4h, resolution 3.10Å

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