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<StructureSection load='5afk' size='340' side='right'caption='[[5afk]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
<StructureSection load='5afk' size='340' side='right'caption='[[5afk]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5afk]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Great_pond_snail Great pond snail]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AFK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AFK FirstGlance]. <br>
<table><tr><td colspan='2'>[[5afk]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lymnaea_stagnalis Lymnaea stagnalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AFK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5VU:N-(2,4-DIFLUOROPHENYL)PYRROLIDINE-1-CARBOXAMIDE'>5VU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L0B:ALPHA-LOBELINE'>L0B</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.381&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5afh|5afh]], [[5afj|5afj]], [[5afl|5afl]], [[5afm|5afm]], [[5afn|5afn]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5VU:N-(2,4-DIFLUOROPHENYL)PYRROLIDINE-1-CARBOXAMIDE'>5VU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L0B:ALPHA-LOBELINE'>L0B</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5afk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5afk OCA], [http://pdbe.org/5afk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5afk RCSB], [http://www.ebi.ac.uk/pdbsum/5afk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5afk ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5afk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5afk OCA], [https://pdbe.org/5afk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5afk RCSB], [https://www.ebi.ac.uk/pdbsum/5afk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5afk ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ACHA7_HUMAN ACHA7_HUMAN] 15q13.3 microdeletion syndrome.
== Function ==
[https://www.uniprot.org/uniprot/ACHP_LYMST ACHP_LYMST] Binds to acetylcholine. Modulates neuronal synaptic transmission.[https://www.uniprot.org/uniprot/ACHA7_HUMAN ACHA7_HUMAN] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Great pond snail]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Atack, J]]
[[Category: Lymnaea stagnalis]]
[[Category: Bertrand, D]]
[[Category: Atack J]]
[[Category: Danielson, U H]]
[[Category: Bertrand D]]
[[Category: Debaveye, S]]
[[Category: Danielson UH]]
[[Category: Farinha, A]]
[[Category: Debaveye S]]
[[Category: Gossas, T]]
[[Category: Farinha A]]
[[Category: Kemp, J]]
[[Category: Gossas T]]
[[Category: Spurny, R]]
[[Category: Kemp J]]
[[Category: Tresadern, G]]
[[Category: Spurny R]]
[[Category: Ulens, C]]
[[Category: Tresadern G]]
[[Category: Veys, K]]
[[Category: Ulens C]]
[[Category: Vos, A]]
[[Category: Veys K]]
[[Category: Allosteric modulation]]
[[Category: Vos A]]
[[Category: Cys-loop receptor]]
[[Category: Drug discovery]]
[[Category: Nicotinic acetylcholine receptor]]
[[Category: Pentameric ligand-gated ion channel]]
[[Category: Transport protein]]

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