Proteopedia

Rab5 GDP/GTP exchange factor: Difference between revisions

← Older edit
Michal Harel (talk | contribs)
31,761 edits
No edit summary
Michal Harel (talk | contribs)
31,761 edits
No edit summary
 
(7 intermediate revisions by 4 users not shown)
Line 1: Line 1:
<StructureSection load='4n3z' size='340' side='right' caption='Human rabex-5 (grey) complex with rabaptin (green and pink) and phosphate ion (PDB code [[4n3z]]).' scene=''>
<StructureSection load='4n3z' size='350' side='right' caption='Human rabex-5 (cyan) complex with rabaptin (green and deeppink) and phosphate ion (PDB code [[4n3z]]).' scene=''>


== Function ==
== Function ==


'''Rab5 GDP/GTP exchange factor''' (Rabex5) is a guanine nucleotide exchange factor.  Rabex5 stimulates nucleotide exchange on Rab5.  Rabex can act as a ubiqiutin ligase. It forms a tight complex with rabaptin which augments its exchange activity.  The rabex5-rabaptin complex is critical to endosomal fusion<ref>PMID:9323142</ref>.
'''Rab5 GDP/GTP exchange factor''' (Rabex5) is a guanine nucleotide exchange factor.  Rabex5 stimulates nucleotide exchange on Rab5.  Rabex can act as a ubiqiutin ligase. It forms a tight complex with rabaptin which augments its exchange activity.  The rabex5-rabaptin complex is critical to endosomal fusion<ref>PMID:9323142</ref>.
== Disease ==
== Relevance ==


== Structural highlights ==
== Structural highlights ==
 
The <scene name='68/680139/Cv/4'>rabapin helix packs against the Rasbex5</scene> forming a 3-helix bundle<ref>PMID:9323142</ref>.
</StructureSection>
</StructureSection>


Line 17: Line 13:
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}


[[1txu]] – hRabex5 Vps9 domain – human<br />
[[1txu]] – hRabex5 Vps9 domain 133-394 – human<br />
[[4n3x]] – hRabex5 CC domain <br />
[[4n3x]] – hRabex5 CC domain 626-672 <br />
[[2fid]], [[2fif]] – bRabex5 zinc finger and ubiquitin interacting motif + ubiquitin – bovine<br />
[[2c7m]], [[2c7n]] – hRabex5 ubiquitin interacting motif 1-74 + ubiquitin <br />
[[2c7m]], [[2c7n]] – hRabex5 ubiquitin interacting motif + ubiquitin <br />
[[2ot3]] – hRabex5 Vps9 domain + Ras-related protein Rab21<br />
[[2ot3]] – hRabex5 Vps9 domain + Ras-related protein Rab21<br />
[[4n3x]] – hRabex5 CC domain + Rabaptin<br />
[[4n3z]] – hRabex5 5δ 132-455 + Rabaptin<br />
[[4n3z]] – hRabex5 5δ + Rabaptin<br />
[[4q9u]] – hRabex5 5δ (mutant) + Ras-related protein Rab5A<br />
[[4q9u]] – hRabex5 5δ (mutant) + Ras-related protein Rab5A<br />
[[4n3y]] – hRabex5 5CC domain + Rab GTPase-binding effector protein<br />
[[4n3y]] – hRabex5 CC domain + Rab GTPase-binding effector protein<br />
[[2fid]], [[2fif]] – bRabex5 zinc finger and ubiquitin interacting motif + ubiquitin – bovine<br />




Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
Retrieved from "https://proteopedia.openfox.io/w/Rab5_GDP/GTP_exchange_factor"