6hpv: Difference between revisions

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<StructureSection load='6hpv' size='340' side='right'caption='[[6hpv]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='6hpv' size='340' side='right'caption='[[6hpv]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6hpv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HPV FirstGlance]. <br>
<table><tr><td colspan='2'>[[6hpv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HPV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Fetub ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hpv OCA], [http://pdbe.org/6hpv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hpv RCSB], [http://www.ebi.ac.uk/pdbsum/6hpv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hpv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hpv OCA], [https://pdbe.org/6hpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hpv RCSB], [https://www.ebi.ac.uk/pdbsum/6hpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hpv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FETUB_MOUSE FETUB_MOUSE]] Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening.<ref>PMID:23562279</ref>
[https://www.uniprot.org/uniprot/FETUB_MOUSE FETUB_MOUSE] Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening.<ref>PMID:23562279</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Dietzel, E]]
[[Category: Dietzel E]]
[[Category: Fahrenkamp, D]]
[[Category: Fahrenkamp D]]
[[Category: Jovine, L]]
[[Category: Jovine L]]
[[Category: Sanctis, D de]]
[[Category: De Sanctis D]]
[[Category: Cystatin domain]]
[[Category: Egg coat]]
[[Category: Fertilization]]
[[Category: Glycoprotein]]
[[Category: Hardening]]
[[Category: Hydrolase inhibitor]]
[[Category: Liver-secreted protein]]
[[Category: Metalloprotease inhibitor]]
[[Category: Ovastacin]]
[[Category: Zona pellucida]]
[[Category: Zp2]]

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