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| <StructureSection load='2je6' size='340' side='right' caption='Exosome complex containing exonuclease 1 (green), exonuclease 2 (grey) and exosome complex RNA-binding protein 1 (wheat) complex with PEG400 (pdb code [[2je6]]).' scene=''> | | <StructureSection load='2je6' size='340' side='right' caption='Exosome complex containing exonuclease 1 (green), exonuclease 2 (grey) and exosome complex RNA-binding protein 1 (wheat) complex with PEG400 (pdb code [[2je6]]).' scene=''> |
| The '''Exosome complex''' (or just- Exosome) is a multi-protein complex capable of degrading various types of RNA molecules. The Exosome complex is found in eukaryotic cell, and also in archaea, while in bacteria it is found as a simpler complex (but it has the same function). <ref>http://en.wikipedia.org/wiki/Exosome_complex#Structure</ref> | | The '''Exosome complex''' (or just- Exosome) is a multi-protein complex capable of degrading various types of RNA molecules. The Exosome complex is found in eukaryotic cell, and also in archaea, while in bacteria it is found as a simpler complex (but it has the same function). <ref>http://en.wikipedia.org/wiki/Exosome_complex#Structure</ref> |
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| | Some of the exosome components are:<br /> |
| | *'''MTR3''' and '''SKI6''' are part of RNase PH domain-containing subunits proposed to form a central channel which threads RNA for degradation.<br /> |
| | *'''MTR4''' interacts with Nop53 and together they have a role in the maturation of 5.8S rRNA<ref>PMID:28883156</ref>.<br /> |
| | *'''Rrp6''' is a nuclear-specific subunit promoting cell survival during heat stress<ref>PMID:32521279</ref>.<br /> |
| | *'''Rrp44''' is the catalytic subunit <ref>PMID:19060898</ref>.<br /> |
| | *'''Csl4''' is required for mRNA decay.<br /> |
| | *'''M-phase phosphoprotein 6''' is involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA. |
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| __TOC__ | | __TOC__ |
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| </StructureSection> | | </StructureSection> |
| ==3D structures of exosome==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Exosome
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| **[[2cpr]] – hRRP6 HRDC domain – human - NMR<br />
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| **[[3saf]], [[3sag]], [[3sah]] – hRRP6 catalytic domain (mutant)<br />
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| **[[6ieg]] – hMTR4<br />
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| **[[6ieh]] – hMTR4 + NRDE2<br />
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| **[[2nn6]] – hCSL4 + RRP40 + RRP41 + RRP42 + RRP43 + RRP44 + RRP45 + RRP46 + RRP4 + MTR3 <br />
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| **[[2je6]], [[2br2]] – SsRRP4 + RRP41 + RRP42 – ''Sulfolobus solfataricus'' <br />
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| **[[2jeb]] - SsRRP4 + RRP41 + RRP42 + exonuclease 1 + RNA-binding protein 1 + Mn<br />
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| **[[2ba0]] – AfRRP4 + RRP41 + RRP42 – Archaeoglobus fulgidus<br />
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| **[[2ba1]] – AfCSL4 + RRP41 + RRP42 <br />
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| **[[2hbj]], [[2hbk]] – yRRP6 (mutant) - yeast<br />
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| **[[2ja9]] – yRRP6 <br />
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| **[[2hbl]], [[2hbm]] – yRRP6 (mutant) + nucleotide<br />
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| **[[4wfc]] – yRRP6 +RRP47 <br />
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| **[[4wfd]] – yRRP6 +RRP47 + MTR4<br />
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| **[[2wp8]] – yRRP45 + SKI6 + DIS3<br />
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| **[[5okz]] – yCSL4 + RRP40 + RRP42 + RRP43 + RRP45 + RRP46 + RRP4 + SKI6 + MTR3 + M-phase phosphoprotein 6 <br />
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| **[[5g06]] – yCSL4 + RRP40 + RRP42 + RRP43 + RRP45 + RRP46 + RRP4 + RRP6 + SKI6 + MTR3 + superkiller protein 7 + DIS3 <br />
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| *Exosome complex with RNA
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| **[[6h25]] – hCSL4 + RRP40 + RRP41 + RRP42 + RRP43 + RRP44 + RRP45 + RRP46 + RRP4 + MTR3 + M-phase phosphoprotein 6 + RNA – Cryo EM<br />
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| **[[6d6r]], [[6d6q]] – hCSL4 + RRP40 + RRP41 + RRP42 + RRP43 + RRP44 + RRP45 + RRP46 + RRP4 + MTR3 + MTR4 + component 10 + M-phase phosphoprotein 6 + DNA/RNA + RNA – Cryo EM<br />
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| **[[2jea]] - SsRRP4 + RRP41 + RRP42 + exonuclease 1 + RNA-binding protein 1 + RNA<br />
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| **[[3m7n]] – AfCSL4 + RRP41 + RRP42 + RNA<br />
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| **[[2m85]] – AfCSL4 + RRP41 (mutant) + RRP42 (mutant) + RNA<br />
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| **[[2vnu]], [[5c0y]] – yRRP6 + RNA<br />
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| **[[4ifd]] – yCSL4 + RRP40 + RRP41 + RRP42 + RRP43 + RRP44 + RRP45 + RRP46 + RRP4 + MTR3 + RNA <br />
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| **[[4oo1]] – yCSL4 + RRP40 + RRP42 + RRP43 + RRP45 + RRP46 + RRP4 + RRP6 + SKI6 + MTR3 + RNA <br />
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| **[[5vzj]] – yCSL4 + RRP40 + RRP42 + RRP43 + RRP45 + RRP46 + RRP4 + RRP6 + SKI6 + MTR3 + M-phase phosphoprotein 6 + DIS3 + RNA <br />
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| **[[5k36]], [[5c0x]], [[5c0w]] – yCSL4 + RRP40 + RRP42 + RRP43 + RRP45 + RRP46 + RRP4 + RRP6 + SKI6 + MTR3 + DIS3 + RNA <br />
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| **[[5jea]] – yCSL4 + RRP40 + RRP42 + RRP43 + RRP45 + RRP46 + RRP4 + RRP6 + SKI6 + MTR3 + superkiller protein 7 + DIS3 + RNA <br />
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| **[[5jea]] – yCSL4 + RRP40 + RRP42 + RRP43 + RRP45 + RRP46 + RRP4 + RRP6 + SKI6 + MTR3 + LRP1 + RNA <br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category: Topic Page]] | | [[Category: Topic Page]] |