Exosome: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Nitzan Dubovski, Michal Harel

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 <StructureSection load='2je6' size='340' side='right' caption='Exosome complex containing exonuclease 1 (green), exonuclease 2 (grey) and exosome complex RNA-binding protein 1 (wheat) complex with PEG400 (pdb code [[2je6]]).' scene=''>
 The '''Exosome complex''' (or just- Exosome) is a multi-protein complex capable of degrading various types of RNA molecules. The Exosome complex is found in eukaryotic cell, and also in archaea, while in bacteria it is found as a simpler complex (but it has the same function). <ref>http://en.wikipedia.org/wiki/Exosome_complex#Structure</ref>
+Some of the exosome components are:<br />
+*'''MTR3''' and '''SKI6''' are part of RNase PH domain-containing subunits proposed to form a central channel which threads RNA for degradation.<br />
+*'''MTR4''' interacts with Nop53 and together they have a role in the maturation of 5.8S rRNA<ref>PMID:28883156</ref>.<br />
+*'''Rrp6''' is a nuclear-specific subunit promoting cell survival during heat stress<ref>PMID:32521279</ref>.<br />
+*'''Rrp44''' is the catalytic subunit <ref>PMID:19060898</ref>.<br />
+*'''Csl4''' is required for mRNA decay.<br />
+*'''M-phase phosphoprotein 6''' is involved in the 3'-processing  of the 7S pre-RNA to the mature 5.8S rRNA.
 __TOC__
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 You can also view the complex in a <scene name="/12/3456/Sample/2">ribbon view</scene>.
-</StructureSection>
 ==3D structures of exosome==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+[[Exosome 3D structures]]
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Exosome
+</StructureSection>
-**[[2je6]], [[2br2]] – SsRRP4 + RRP41 + RRP42 – Sulfolobus solfataricus <br />
-**[[2jeb]] - SsRRP4 + RRP41 + RRP42 + exonuclease 1 + RNA-binding protein 1 + Mn<br />
-**[[2ba0]] – AfRRP4 + RRP41 + RRP42 – Archaeoglobus fulgidus<br />
-**[[2ba1]] – AfCSL4 + RRP41 + RRP42 <br />
-**[[2nn6]] – hCSL4 + RRP40 + RRP41 + RRP42 + RRP43 + RRP44 + RRP45 + RRP46 + RRP4 + MTR3 - human<br />
-**[[2hbj]], [[2hbk]] – yRRP6 (mutant) <br />
-**[[2hbl]], [[2hbm]] – yRRP6 (mutant) + nucleotide<br />
-**[[4wfc]] – yRRP6 +RRP47 <br />
-**[[4wfd]] – yRRP6 +RRP47 + MTR4<br />
-**[[2cpr]] – hRRP6 HRDC domain – NMR<br />
-**[[3saf]], [[3sag]], [[3sah]] – hRRP6 catalytic domain (mutant)<br />
-*Exosome complex with RNA
-**[[2jea]] - SsRRP4 + RRP41 + RRP42 + exonuclease 1 + RNA-binding protein 1 + RNA<br />
-**[[3m7n]] – AfCSL4 + RRP41 + RRP42 + RNA<br />
-**[[2m85]] – AfCSL4 + RRP41 (mutant) + RRP42 (mutant) + RNA<br />
-**[[4ifd]] – yCSL4 + RRP40 + RRP41 + RRP42 + RRP43 + RRP44 + RRP45 + RRP46 + RRP4 + MTR3 + RNA - yeast<br />
-**[[4oo1]] – yCSL4 + RRP40 + RRP42 + RRP43 + RRP45 + RRP46 + RRP4 + RRP6 + SKI6 + MTR3 + RNA <br />
-}}
 == References ==
 <references/>
 [[Category: Topic Page]]