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==Crystal Structure of Surfactant Protein-A DED Mutant (E171D/P175E/K203D)== | ==Crystal Structure of Surfactant Protein-A DED Mutant (E171D/P175E/K203D)== | ||
<StructureSection load='4wr9' size='340' side='right' caption='[[4wr9]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='4wr9' size='340' side='right'caption='[[4wr9]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4wr9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WR9 OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4wr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WR9 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.301Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wr9 OCA], [https://pdbe.org/4wr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wr9 RCSB], [https://www.ebi.ac.uk/pdbsum/4wr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wr9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/SFTPA_RAT SFTPA_RAT] In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Rattus norvegicus]] | ||
[[Category: | [[Category: Cafarella TR]] | ||
[[Category: | [[Category: Head JF]] | ||
[[Category: | [[Category: McCormack FX]] | ||
[[Category: | [[Category: Nikolaidis NM]] | ||
[[Category: | [[Category: Rynkiewicz MJ]] | ||
[[Category: | [[Category: Seaton BA]] | ||
[[Category: | [[Category: Wu H]] | ||
Latest revision as of 11:33, 23 October 2024
Crystal Structure of Surfactant Protein-A DED Mutant (E171D/P175E/K203D)Crystal Structure of Surfactant Protein-A DED Mutant (E171D/P175E/K203D)
Structural highlights
FunctionSFTPA_RAT In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. |
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