4v2q: Difference between revisions
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==Ironing out their differences: Dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase== | ==Ironing out their differences: Dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase== | ||
<StructureSection load='4v2q' size='340' side='right' caption='[[4v2q]], [[Resolution|resolution]] 1.95Å' scene=''> | <StructureSection load='4v2q' size='340' side='right'caption='[[4v2q]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4v2q]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V2Q OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4v2q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Taxus_chinensis Taxus chinensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V2Q FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v2q OCA], [https://pdbe.org/4v2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v2q RCSB], [https://www.ebi.ac.uk/pdbsum/4v2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v2q ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PAM_TAXCH PAM_TAXCH] Phenylalanine aminomutase that catalyzes the rearrangement of L-phenylalanine to R-beta-phenylalanine. Catalyzes the first committed step in the biosynthesis of the side chain of the alkaloid taxol (paclitaxel), a widely-used compound with antitumor activity. Has also low phenylalanine ammonia-lyase activity and can catalyze the amination of trans-cinnamate.<ref>PMID:15878763</ref> <ref>PMID:22113970</ref> <ref>PMID:24786474</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4v2q" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Aminomutase 3D structures|Aminomutase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Bartsch | [[Category: Taxus chinensis]] | ||
[[Category: Dijkstra | [[Category: Bartsch S]] | ||
[[Category: Heberling | [[Category: Dijkstra BW]] | ||
[[Category: Janssen | [[Category: Heberling M]] | ||
[[Category: Marrink | [[Category: Janssen D]] | ||
[[Category: Masman | [[Category: Marrink S]] | ||
[[Category: Wybenga | [[Category: Masman M]] | ||
[[Category: Wybenga GG]] | |||