4v2d: Difference between revisions
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<StructureSection load='4v2d' size='340' side='right'caption='[[4v2d]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='4v2d' size='340' side='right'caption='[[4v2d]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4v2d]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4v2d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V2D FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v2d OCA], [https://pdbe.org/4v2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v2d RCSB], [https://www.ebi.ac.uk/pdbsum/4v2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v2d ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/FLRT2_MOUSE FLRT2_MOUSE] Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:21350012, PubMed:25728924 PubMed:25374360). May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D (PubMed:21673655). Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members (PubMed:21673655, PubMed:25728924). Plays a role in fibroblast growth factor-mediated signaling cascades (PubMed:16872596). Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis (PubMed:21350012).<ref>PMID:16872596</ref> <ref>PMID:21350012</ref> <ref>PMID:21673655</ref> <ref>PMID:25374360</ref> <ref>PMID:25728924</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Acker-Palmer | [[Category: Acker-Palmer A]] | ||
[[Category: Border | [[Category: Border EC]] | ||
[[Category: Cop | [[Category: Cop F]] | ||
[[Category: Haertl | [[Category: Haertl R]] | ||
[[Category: Harlos | [[Category: Harlos K]] | ||
[[Category: Jones | [[Category: Jones EY]] | ||
[[Category: Klein | [[Category: Klein R]] | ||
[[Category: Nagel | [[Category: Nagel D]] | ||
[[Category: Ruff | [[Category: Ruff T]] | ||
[[Category: Seiradake | [[Category: Seiradake E]] | ||
[[Category: Seyit-Bremer | [[Category: Seyit-Bremer G]] | ||
[[Category: Toro | [[Category: Del Toro D]] | ||