4v2d: Difference between revisions

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OCA

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 ==FLRT2 LRR domain==
-<StructureSection load='4v2d' size='340' side='right' caption='[[4v2d]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+<StructureSection load='4v2d' size='340' side='right'caption='[[4v2d]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4v2d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V2D FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4v2d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V2D FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4v2a|4v2a]], [[4v2b|4v2b]], [[4v2c|4v2c]], [[4v2e|4v2e]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v2d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v2d RCSB], [http://www.ebi.ac.uk/pdbsum/4v2d PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v2d OCA], [https://pdbe.org/4v2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v2d RCSB], [https://www.ebi.ac.uk/pdbsum/4v2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v2d ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/FLRT2_MOUSE FLRT2_MOUSE] Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:21350012, PubMed:25728924 PubMed:25374360). May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D (PubMed:21673655). Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members (PubMed:21673655, PubMed:25728924). Plays a role in fibroblast growth factor-mediated signaling cascades (PubMed:16872596). Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis (PubMed:21350012).<ref>PMID:16872596</ref> <ref>PMID:21350012</ref> <ref>PMID:21673655</ref> <ref>PMID:25374360</ref> <ref>PMID:25728924</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 14: / Line 17: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4v2d" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Acker-Palmer, A]]
+[[Category: Homo sapiens]]
-[[Category: Border, E C]]
+[[Category: Large Structures]]
-[[Category: Cop, F]]
+[[Category: Acker-Palmer A]]
-[[Category: Haertl, R]]
+[[Category: Border EC]]
-[[Category: Harlos, K]]
+[[Category: Cop F]]
-[[Category: Jones, E Y]]
+[[Category: Haertl R]]
-[[Category: Klein, R]]
+[[Category: Harlos K]]
-[[Category: Nagel, D]]
+[[Category: Jones EY]]
-[[Category: Ruff, T]]
+[[Category: Klein R]]
-[[Category: Seiradake, E]]
+[[Category: Nagel D]]
-[[Category: Seyit-Bremer, G]]
+[[Category: Ruff T]]
-[[Category: Toro, D del]]
+[[Category: Seiradake E]]
-[[Category: Leucine-rich repeat]]
+[[Category: Seyit-Bremer G]]
-[[Category: Signaling protein]]
+[[Category: Del Toro D]]
-[[Category: Unc5]]