4wjg: Difference between revisions
New page: '''Unreleased structure''' The entry 4wjg is ON HOLD until sometime in the future Authors: Stoedkilde, K., Torvund-Jensen, M., Moestrup, S.K., Andersen, C.B.F. Description: Structure o... |
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The | ==Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin== | ||
<StructureSection load='4wjg' size='340' side='right'caption='[[4wjg]], [[Resolution|resolution]] 3.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4wjg]] is a 30 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_N315 Staphylococcus aureus subsp. aureus N315] and [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WJG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WJG FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wjg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wjg OCA], [https://pdbe.org/4wjg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wjg RCSB], [https://www.ebi.ac.uk/pdbsum/4wjg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wjg ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ISDH_STAAN ISDH_STAAN] Binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. Binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone (By similarity). | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Sleeping sickness is caused by trypanosome parasites, which infect humans and livestock in Sub-Saharan Africa. Haem is an important growth factor for the parasites and is acquired from the host by receptor-mediated uptake of haptoglobin (Hp)-haemoglobin (Hb) complexes. The parasite Hp-Hb receptor (HpHbR) is also a target for a specialized innate immune defence executed by trypanosome-killing lipoprotein particles containing an Hp-related protein in complex with Hb. Here we report the structure of the multimeric complex between human Hp-Hb and Trypanosoma brucei brucei HpHbR. Two receptors forming kinked three-helical rods with small head regions bind to Hp and the beta-subunits of Hb (betaHb), with one receptor at each end of the dimeric Hp-Hb complex. The Hb beta-subunit haem group directly associates with the receptors, which allows for sensing of haem-containing Hp-Hb. The HpHbR-binding region of Hp is conserved in Hp-related protein, indicating an identical recognition of Hp-Hb and trypanolytic particles by HpHbR in human plasma. | |||
Structural basis for trypanosomal haem acquisition and susceptibility to the host innate immune system.,Stodkilde K, Torvund-Jensen M, Moestrup SK, Andersen CB Nat Commun. 2014 Nov 20;5:5487. doi: 10.1038/ncomms6487. PMID:25410714<ref>PMID:25410714</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4wjg" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Haptoglobin receptor|Haptoglobin receptor]] | |||
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Staphylococcus aureus subsp. aureus N315]] | |||
[[Category: Trypanosoma brucei brucei]] | |||
[[Category: Andersen CBF]] | |||
[[Category: Moestrup SK]] | |||
[[Category: Stoedkilde K]] | |||
[[Category: Torvund-Jensen M]] | |||