4r5r: Difference between revisions
New page: '''Unreleased structure''' The entry 4r5r is ON HOLD Authors: Huang, C.H., Shiu, J.H., Chang, Y.T., Jeng, W.Y., Chuang, W.J. Description: Crystal structure of Rhodostomin KKKRT mutant |
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==Crystal structure of Rhodostomin KKKRT mutant== | |||
<StructureSection load='4r5r' size='340' side='right'caption='[[4r5r]], [[Resolution|resolution]] 0.96Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4r5r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R5R FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.96Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r5r OCA], [https://pdbe.org/4r5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r5r RCSB], [https://www.ebi.ac.uk/pdbsum/4r5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r5r ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). | |||
==See Also== | |||
*[[Disintegrin|Disintegrin]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Calloselasma rhodostoma]] | |||
[[Category: Large Structures]] | |||
[[Category: Chang YT]] | |||
[[Category: Chuang WJ]] | |||
[[Category: Huang CH]] | |||
[[Category: Jeng WY]] | |||
[[Category: Shiu JH]] | |||