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Geranylgeranyl transferase: Difference between revisions

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== Function ==
== Function ==


'''Geranylgeranyl transferase''' type 1 (GGT1) adds a 20-carbon isoprenoid group called geranylgeranyl (GG) to the C-terminal of proteins containg the CAAX motif (Cysteine, Aliphatic, Aliphatic, any amino acid).  '''Geranylgeranyl transferase type 2''' (GGT2) adds 2 GG groups to C-terminal cysteine residue of a protein.  The addition of the hydrophobic prenyl group causes the proteins to become membrane-associated<ref>PMID:16477080</ref>.  
'''Geranylgeranyl transferase''' '''type 1''' (GGT1) adds a 20-carbon isoprenoid group called geranylgeranyl (GG) to the C-terminal of proteins containing the CAAX motif (Cysteine, Aliphatic, Aliphatic, any amino acid).  '''Geranylgeranyl transferase type 2''' (GGT2) adds 2 GG groups to C-terminal cysteine residue of a protein.  The addition of the hydrophobic prenyl group causes the proteins to become membrane-associated<ref>PMID:16477080</ref>.  


== Relevance ==
== Relevance ==
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The <scene name='59/597443/Cv/5'>active site with bound geranylgeranyl pyrophosphate</scene> contains a <scene name='59/597443/Cv/6'>Zn+2 atom</scene><ref>PMID:18756270</ref>. Water molecules shown as red spheres.
The <scene name='59/597443/Cv/5'>active site with bound geranylgeranyl pyrophosphate</scene> contains a <scene name='59/597443/Cv/6'>Zn+2 atom</scene><ref>PMID:18756270</ref>. Water molecules shown as red spheres.
</StructureSection>


==3D structures of eranylgeranyl transferase==
==3D structures of geranylgeranyl transferase==
[[Geranylgeranyl transferase 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Geranylgeranyl transferase type 1
 
**[[1s64]] – rGGT1  α+β subunits + inhibitor - rat<br />
**[[1n4p]] – rGGT1 α+β subunits + GGPP<br />
**[[1n4s]], [[1n4r]] – rGGT1 α+β subunits + GGPP + peptide-GG containing CAAX <br />
**[[1tnb]], [[1tno]], [[1tnu]], [[1tny]], [[1tnz]], [[1n4q]] – rGGT1 α+β subunits + GGPP analog + peptide containing CAAX<br />
**[[3dra]] – GGT1 α+β subunits + GGPP – ''Candida albicans''<br />
 
*Geranylgeranyl transferase type 2
 
**[[1dce]] – rGGT2 α+β subunits – rat<br />
**[[3dss]] – rGGT2 α+β subunits <br />
 
*Geranylgeranyl transferase type 2 complex


**[[3c72]], [[3pz1]], [[3pz3]], [[4ehm]], [[4gts]], [[4gtt]], [[4gtv]] – rGGT2 α+β subunits + inhibitor<br />
**[[3hxb]], [[3hxc]], [[3hxd]], [[3hxe]], [[3hxf]] – rGGT2 α (mutant) +β subunits + inhibitor<br />
**[[1ltx]] – rGGT α+β subunits + tetra-alanine + Rab escort protein + farnesyl<br />
**[[3dst]] – rGGT2 α+β subunits + GGPP<br />
**[[3dsu]] – rGGT2 α+β subunits + farnesyl-PP<br />
**[[3dsv]], [[3dsw]], [[3dsx]] – rGGT2 α+β subunits + GG<br />
**[[3pz2]] – rGGT2 α+β subunits + GGPP + inhibitor<br />
}}
== References ==
== References ==
<references/>
<references/>


[[Category:Topic Page]]
[[Category:Topic Page]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky
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