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Centromere protein: Difference between revisions

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•      '''CENP-B''' facilitates centromere formation.<ref>PMID:11726497</ref><br />
•      '''CENP-B''' facilitates centromere formation.<ref>PMID:11726497</ref><br />
• '''CENP-A''' is a component of modified nucleosome replacing hitone H3.<ref>PMID:20739937</ref><br />
• '''CENP-A''' is a component of modified nucleosome replacing hitone H3.<ref>PMID:20739937</ref><br />
• '''CENP-E''' is a motor protein involved inchromosome movement.<ref>PMID:15159587</ref><br />
• '''CENP-E''' is a motor protein involved in chromosome movement.<ref>PMID:15159587</ref><br />
• '''CENP-M''' is involved in the kinetochore assembly.<ref>PMID:25006165</ref><br />
• '''CENP-I''' regulates the recruitment of kinetochore-associated proteins that are required to generate the spindle checkpoint signal.<br />
• '''CENP-M''' and '''CENP-N''' are involved in the kinetochore assembly.<ref>PMID:25006165</ref><br />
• '''Kinetochore''' is a complex essential for accurate chromosome segregation.<ref>PMID:16214339</ref><br />
• '''CENP-mis12''' from fission yeast is required for correct spindle morphogenesis<ref>PMID:10398680</ref>.<br />
*  '''Inner centromere protein''' (INCENP) is a component of the chromosomal passenger complex which regulates mitosis.  INCENP are localized at the centromeres during mid-metaphase of the cell cycle.<ref>PMID:17956729</ref>
*  '''Inner centromere protein''' (INCENP) is a component of the chromosomal passenger complex which regulates mitosis.  INCENP are localized at the centromeres during mid-metaphase of the cell cycle.<ref>PMID:17956729</ref>
• '''CBF3''' is a yeast complex which interacts with centromeric DNA and mediates nucleosome deposition.<ref>PMID:30478265</ref><br />


== Disease ==
== Disease ==


CENP-A is overexpressed in colon cancer.
CENP-A is overexpressed in colon cancer.  A synonymous single nucleotide polymorphism (SNP) in INCENP is associated with breast cancer risk<ref>PMID:25586992</ref>.


== Relevance ==
== Relevance ==
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<scene name='59/596426/Cv/2'>Chicken CENP-T histone fold/CENP-W/CENP-S/CENP-X heterotetrameric complex</scene> (PDB code [[3vh5]]).<ref>PMID:22304917</ref>
<scene name='59/596426/Cv/2'>Chicken CENP-T histone fold/CENP-W/CENP-S/CENP-X heterotetrameric complex</scene> (PDB code [[3vh5]]).<ref>PMID:22304917</ref>
</StructureSection>


==3D structures of centromere protein==
==3D structures of centromere protein==
[[Centromere protein 3D structure]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Centromere proteins X, S, W, T
 
**[[3b0b]] – cCENP-X + CENP-S – chicken<br />
**[[4dra]], [[4e44]], [[4ne3]], [[4ne5]], [[4ne6]] – hCENP-X + CENP-S – human<br />
**[[3vh5]], [[3vh6]] – cCENP-X + CENP-S (mutant) + CENP-W + CENP-T C-terminal (mutant)<br />
**[[4drb]], [[4e45]] – hCENP-X + CENP-S + Fanconi anemia group M protein<br />
**[[4ndy]], [[4ne1]] – hCENP-X + CENP-S + DNA<br />
**[[3b0c]], [[3b0d]] – cCENP-T + CENP-W<br />
**[[3vza]] – cCENP-T residues 63-98 (mutant) + Spc24 + Spc25<br />
 
*Inner centromere protein
 
**[[2bfx]], [[4b8l]] – fINCENP residues 798-840 + aurora kinase – frog<br />
**[[2bfy]] – fINCENP residues 798-840 + aurora kinase + hesperadin<br />
**[[2vgp]], [[2vrx]], [[3ztx]], [[4b8m]], [[5k3y]], [[5eyk]] – fINCENP residues 798-840 + aurora kinase + inhibitor<br />
**[[4af3]] – hINCENP residues 835-903 + aurora kinase + inhibitor<br />
**[[2vgo]] – fINCENP residues 798-840 + aurora kinase + reversine<br />
**[[4c2v]] – fINCENP residues 798-840 + aurora kinase + barasertib<br />
**[[4c2w]] – fINCENP residues 798-840 + aurora kinase + AMPPNP<br />
**[[2qfa]] – hINCENP residues 1-47 + surviving + borealin<br />
 
*Centromere protein A
 
**[[3nqu]] – hCENP-A + histone H4<br />
**[[3nqj]] – hCENP-A residues 60-140 + histone H4<br />
**[[3r45]] – hCENP-A + histone H4 + Holliday junction recognition protein<br />
**[[3an2]] – hCENP-A + histone H4 + histone H2A + histone H2B + DNA<br />
**[[6buz]] – hCENP-A + histone H4 + histone H2A + histone H2B + DNA + MBP/CENP-N<br />
 
*Centromere protein C
 
**[[5lsk]], [[5lsj]] – hCENP-C + kinetochore MIS12<br />
 
*Centromere protein B
 
**[[1bw6]] – hCENP-B DNA-binding domain - NMR<br />
**[[1ufi]] – hCENP-B dimerization domain <br />
**[[1hlv]] – hCENP-B DNA-binding domain + DNA<br />
 
*Centromere protein E
 
**[[1t5c]] – hCENP-E motor domain<br />
 
*Centromere protein J
 
**[[5itz]] – hCENP-J + tubulin<br />
 
*Centromere protein M
 
**[[4p0t]], [[4wau]] – hCENP-M<br />
 
*Centromere protein N
 
**[[4wau]] – hCENP-N<br />
**[[6c0w]] – hCENP-N + histone H4 + histone H2A + histone H2B + DNA + CENP-A<br />
 
*Centromere protein mis12
 
**[[5wwl]] – CENP + kinetochore protein NNF1 – fission yeast<br />
 
}}


== References ==
== References ==

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky
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