Centromere protein: Difference between revisions

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Michal Harel, Alexander Berchansky

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-<StructureSection load='3vh5' size='340' side='right' caption='Structure of chicken CENP-X (yellow), CENP-S (grey), CENP-W (purple) and CENP-T C-terminal (dark green) (PDB code [[3vh5]]).' scene=''>
+<StructureSection load='3vh5' size='350' side='right' caption='Structure of chicken CENP-X (yellow), CENP-S (cyan), CENP-W (magenta) and CENP-T C-terminal (green) (PDB code [[3vh5]]).' scene='59/596426/Cv/1'>
+__TOC__
 == Function ==
 '''Centromere proteins''' (CENP) X,S,W,T make up the kinetochore structure on chromatids where the spindle fibers attach during cell division to pull the chromatids apart. <br />
 •	'''CENP-X''' is a component of the Fanconi Anemia core. <br />
-•      '''CENP-B''' facilitates centromere formation.<br />
+•      '''CENP-B''' facilitates centromere formation.<ref>PMID:11726497</ref><br />
-•	'''CENP-A''' is a component of modified nucleosome replacing hitone H3.<br />
+•	'''CENP-A''' is a component of modified nucleosome replacing hitone H3.<ref>PMID:20739937</ref><br />
-•	'''CENP-E''' is a motor protein involved inchromosome movement.<br />
+•	'''CENP-E''' is a motor protein involved in chromosome movement.<ref>PMID:15159587</ref><br />
-•	'''CENP-M''' is involved in the kinetochore assembly.<br />
+•	'''CENP-I''' regulates the recruitment of kinetochore-associated proteins that are required to generate the spindle checkpoint signal.<br />
-*   '''Inner centromere protein''' (INCENP) is a component of the chromosomal passenger complex which regulates mitosis.  INCENP are localized at the centromeres during mid-metaphase of the cell cycle.
+•	'''CENP-M''' and '''CENP-N''' are involved in the kinetochore assembly.<ref>PMID:25006165</ref><br />
+•	'''Kinetochore''' is a complex essential for accurate chromosome segregation.<ref>PMID:16214339</ref><br />
+•	'''CENP-mis12''' from fission yeast is required for correct spindle morphogenesis<ref>PMID:10398680</ref>.<br />
+*   '''Inner centromere protein''' (INCENP) is a component of the chromosomal passenger complex which regulates mitosis.  INCENP are localized at the centromeres during mid-metaphase of the cell cycle.<ref>PMID:17956729</ref>
+•	'''CBF3''' is a yeast complex which interacts with centromeric DNA and mediates nucleosome deposition.<ref>PMID:30478265</ref><br />
 == Disease ==
+CENP-A is overexpressed in colon cancer.  A synonymous single nucleotide polymorphism (SNP) in INCENP is associated with breast cancer risk<ref>PMID:25586992</ref>.
 == Relevance ==
+CENP-B is a potential marker for lung cancer.
 == Structural highlights ==
-</StructureSection>
+<scene name='59/596426/Cv/2'>Chicken CENP-T histone fold/CENP-W/CENP-S/CENP-X heterotetrameric complex</scene> (PDB code [[3vh5]]).<ref>PMID:22304917</ref>
 ==3D structures of centromere protein==
+[[Centromere protein 3D structure]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Centromere proteins X, S, W, T
-**[[3b0b]] – cCENP-X + CENP-S – chicken<br />
-**[[4dra]], [[4e44]], [[4ne3]], [[4ne5]], [[4ne6]] – hCENP-X + CENP-S – human<br />
-**[[3vh5]], [[3vh6]] – cCENP-X + CENP-S (mutant) + CENP-W + CENP-T C-terminal (mutant)<br />
-**[[4drb]], [[4e45]] – hCENP-X + CENP-S + Fanconi anemia group M protein<br />
-**[[4ndy]], [[4ne1]] – hCENP-X + CENP-S + DNA<br />
-**[[3b0c]], [[3b0d]] – cCENP-T + CENP-W<br />
-**[[3vza]] – cCENP-T residues 63-98 (mutant) + Spc24 + Spc25<br />
-*Inner centromere protein
-**[[2bfx]], [[4b8l]] – fINCENP residues 798-840 + aurora kinase – frog<br />
-**[[2bfy]] – fINCENP residues 798-840 + aurora kinase + hesperadin<br />
-**[[2vgp]], [[2vrx]], [[3ztx]], [[4b8m]] – fINCENP residues 798-840 + aurora kinase + inhibitor<br />
-**[[4af3]] – hINCENP residues 835-903 + aurora kinase + inhibitor<br />
-**[[2vgo]] – fINCENP residues 798-840 + aurora kinase + reversine<br />
-**[[4c2v]] – fINCENP residues 798-840 + aurora kinase + barasertib<br />
-**[[4c2w]] – fINCENP residues 798-840 + aurora kinase + AMPPNP<br />
-**[[2qfa]] – hINCENP residues 1-47 + surviving + borealin<br />
-*Centromere protein A
-**[[3nqu]] – hCENP-A + histone H4<br />
-**[[3nqj]] – hCENP-A residues 60-140 + histone H4<br />
-**[[3r45]] – hCENP-A + histone H4 + Holliday junction recognition protein<br />
-**[[3an2]] – hCENP-A + histone H4 + histone H2A + histone H2B + DNA<br />
-*Centromere protein B
-**[[1bw6]] – hCENP-B DNA-binding domain - NMR<br />
-**[[1ufi]] – hCENP-B dimerization domain <br />
-**[[1hlv]] – hCENP-B DNA-binding domain + DNA<br />
-*Centromere protein E
-**[[1t5c]] – hCENP-E motor domain<br />
-*Centromere protein M
-**[[4p0t]], [[4wau]] – hCENP-M<br />
-}}
 == References ==