Ephrin: Difference between revisions
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== Function == | == Function == | ||
'''Ephrins''' (Eph) are the membrane-bound ligands of ephrin receptors. The binding of Eph and ephrin receptors is achieved via cell-cell interaction. Eph/Eph receptor signaling regulates embryonic development, guidance of axon growth, long-term potentiation, angiogenesis and stem-cell differentiation <ref>PMID:17420126</ref>. See also [[Ephrin receptor]], Eph/ephrin signaling pathway]], [[Ephrin Type-A Receptor]]. | '''Ephrins''' (Eph) are the membrane-bound ligands of ephrin receptors. The binding of Eph and ephrin receptors is achieved via cell-cell interaction. Eph/Eph receptor signaling regulates embryonic development, guidance of axon growth, long-term potentiation, angiogenesis and stem-cell differentiation <ref>PMID:17420126</ref>. See also [[Ephrin receptor]], [[Eph/ephrin signaling pathway]], [[Ephrin Type-A Receptor]]. | ||
*'''Ephrin-A3''' has a role in forming precise tonotropy in the auditory brainstem to ensure accurate sound discrimination<ref>PMID:34235739</ref>. | |||
*'''Ephrin-A5''' is required for the proper guidance and mapping of retinal axons in the mammalian midbrain<ref>PMID:9491985</ref>. | |||
*'''Ephrin-B1''' has a role in palatal shelf outgrowth<ref>PMID:20844017</ref>. | |||
*'''Ephrin-B2''' is a regulator of VEGFR signalling and thus controls angiogenic growth<ref>PMID:20445537</ref>. | |||
*'''Ephrin-B3''' plays a key role at the midline to regulate axonal crossing<ref>PMID:11297511</ref>. | |||
== Disease == | == Disease == | ||
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**[[4uf7]], [[6pdl]] – hEph extracellular domain + glycoprotein <br /> | **[[4uf7]], [[6pdl]] – hEph extracellular domain + glycoprotein <br /> | ||
**[[2vsk]], [[2vsm]] – hEph extracellular domain + virus hemagglutinin neuraminidase <br /> | **[[2vsk]], [[2vsm]] – hEph extracellular domain + virus hemagglutinin neuraminidase <br /> | ||
**[[1iko]] – mEph ectodomain <br /> | **[[1iko]], [[7s7k]] – mEph ectodomain <br /> | ||
**[[1kgy]] – mEph extracellular domain + Eph type B receptor 2 <br /> | **[[1kgy]] – mEph extracellular domain + Eph type B receptor 2 <br /> | ||
**[[2hle]] – mEph extracellular domain + Eph type B receptor 4 <br /> | **[[2hle]] – mEph extracellular domain + Eph type B receptor 4 <br /> | ||