Ephrin: Difference between revisions
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== Function == | == Function == | ||
'''Ephrins''' (Eph) are the membrane-bound ligands of ephrin receptors. The binding of Eph and ephrin receptors is achieved via cell-cell interaction. Eph/Eph receptor signaling regulates embryonic development, guidance of axon growth, long-term potentiation, angiogenesis and stem-cell differentiation <ref>PMID:17420126</ref>. See also [[Ephrin receptor]] | '''Ephrins''' (Eph) are the membrane-bound ligands of ephrin receptors. The binding of Eph and ephrin receptors is achieved via cell-cell interaction. Eph/Eph receptor signaling regulates embryonic development, guidance of axon growth, long-term potentiation, angiogenesis and stem-cell differentiation <ref>PMID:17420126</ref>. See also [[Ephrin receptor]], [[Eph/ephrin signaling pathway]], [[Ephrin Type-A Receptor]]. | ||
*'''Ephrin-A3''' has a role in forming precise tonotropy in the auditory brainstem to ensure accurate sound discrimination<ref>PMID:34235739</ref>. | |||
*'''Ephrin-A5''' is required for the proper guidance and mapping of retinal axons in the mammalian midbrain<ref>PMID:9491985</ref>. | |||
*'''Ephrin-B1''' has a role in palatal shelf outgrowth<ref>PMID:20844017</ref>. | |||
*'''Ephrin-B2''' is a regulator of VEGFR signalling and thus controls angiogenic growth<ref>PMID:20445537</ref>. | |||
*'''Ephrin-B3''' plays a key role at the midline to regulate axonal crossing<ref>PMID:11297511</ref>. | |||
== Disease == | == Disease == | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
*Ephrin-A1 | |||
**[[3hei]], [[3mbw]], [[3czu]] – hEph receptor-binding domain + Eph type A receptor 2 <br /> | |||
**[[3fl7]] – hEph ectodomain <br /> | |||
*Ephrin-A2 | |||
**[[2wo3]] – hEph receptor-binding domain + Eph type A receptor 4 <br /> | |||
* Ephrin-A3 | |||
**[[3dzq]] – hEph kinase domain + inhibitor <br /> | |||
*Ephrin-A5 | *Ephrin-A5 | ||
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**[[1shx]] – mEph receptor-binding domain – mouse<br /> | **[[1shx]] – mEph receptor-binding domain – mouse<br /> | ||
**[[1shw]] – mEph residues 88-225 + Eph type B receptor 2 <br /> | **[[1shw]] – mEph residues 88-225 + Eph type B receptor 2 <br /> | ||
*Ephrin-B1 | |||
**[[6thg]] – hEph extracellular domain 27-170 + glycoprotein <br /> | |||
**[[6p7s]] – mEph extracellular domain + glycoprotein <br /> | |||
*Ephrin-B2 | *Ephrin-B2 | ||
**[[2i85]] – hEph residues 1-142 – NMR<br /> | **[[2i85]] – hEph residues 1-142 – NMR<br /> | ||
**[[2wo2]], [[3gxu]] – hEph | **[[2wo2]], [[3gxu]] – hEph extracellular domain + Eph type A receptor 4 <br /> | ||
**[[4uf7]] – hEph | **[[4uf7]], [[6pdl]] – hEph extracellular domain + glycoprotein <br /> | ||
**[[2vsk]], [[2vsm]] – hEph | **[[2vsk]], [[2vsm]] – hEph extracellular domain + virus hemagglutinin neuraminidase <br /> | ||
**[[1iko]] – mEph ectodomain <br /> | **[[1iko]], [[7s7k]] – mEph ectodomain <br /> | ||
**[[1kgy]] – mEph | **[[1kgy]] – mEph extracellular domain + Eph type B receptor 2 <br /> | ||
**[[2hle]] – mEph | **[[2hle]] – mEph extracellular domain + Eph type B receptor 4 <br /> | ||
**[[6p7y]] – mEph extracellular domain + glycoprotein <br /> | |||
*Ephrin-B3 | *Ephrin-B3 | ||
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**[[4bkf]] – hEph receptor-binding domain + Eph type A receptor 4 <br /> | **[[4bkf]] – hEph receptor-binding domain + Eph type A receptor 4 <br /> | ||
**[[3d12]] – mEph receptor-binding domain + virus hemagglutinin neuraminidase <br /> | **[[3d12]] – mEph receptor-binding domain + virus hemagglutinin neuraminidase <br /> | ||
}} | }} | ||