Ephrin: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

@@ Line 1: / Line 1: @@
-<StructureSection load='3mx0' size='340' side='right' caption='Structure of human ephrin-A5 receptor-binding domain (green and yellow) complex with ephrin type A receptor 2 (grey and pink) (PDB code [[3mx0]]).' scene=''>
+<StructureSection load='' size='340' side='right' caption='Structure of glycosylated human ephrin-A5 receptor-binding domain (green) complex with ephrin type A receptor 2 (cyan) (PDB code [[3mx0]]).' scene='59/594659/Cv/5'>
 == Function ==
-'''Ephrins''' (Eph) are the membrane-bound ligands of ephrin receptors.  The binding of Eph and ephrin receptors is achieved via cell-cell interaction.  Eph/Eph receptor signaling regulates embryonic development, guidance of axon growth, long-term potentiation, angiogenesis and stem-cell differentiation.
+'''Ephrins''' (Eph) are the membrane-bound ligands of ephrin receptors.  The binding of Eph and ephrin receptors is achieved via cell-cell interaction.  Eph/Eph receptor signaling regulates embryonic development, guidance of axon growth, long-term potentiation, angiogenesis and stem-cell differentiation <ref>PMID:17420126</ref>. See also [[Ephrin receptor]], [[Eph/ephrin signaling pathway]], [[Ephrin Type-A Receptor]].
+*'''Ephrin-A3''' has a role in forming precise tonotropy in the auditory brainstem to ensure accurate sound discrimination<ref>PMID:34235739</ref>.
+*'''Ephrin-A5''' is required for the proper guidance and mapping of retinal axons in the mammalian midbrain<ref>PMID:9491985</ref>.
+*'''Ephrin-B1''' has a role in palatal shelf outgrowth<ref>PMID:20844017</ref>.
+*'''Ephrin-B2''' is a regulator of VEGFR signalling and thus controls angiogenic growth<ref>PMID:20445537</ref>.
+*'''Ephrin-B3''' plays a key role at the midline to regulate axonal crossing<ref>PMID:11297511</ref>.
 == Disease ==
+Eph-A5 is implicated in spinal cord injury.  Eph-A1 is implicated in myocardial injury and renal reperfusion injury.
-== Relevance ==
+== Structural highlights ==
-== Structural highlights ==
+<scene name='59/594659/Cv/4'>Ephrin-A5 receptor-binding domain complex with ephrin type A receptor 2</scene> (PDB code [[3mx0]]).<ref>PMID:20505120</ref>
 </StructureSection>
@@ Line 16: / Line 22: @@
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 {{#tree:id=OrganizedByTopic|openlevels=0|
+*Ephrin-A1
+**[[3hei]], [[3mbw]], [[3czu]] – hEph receptor-binding domain + Eph type A receptor 2 <br />
+**[[3fl7]] – hEph ectodomain  <br />
+*Ephrin-A2
+**[[2wo3]] – hEph receptor-binding domain + Eph type A receptor 4 <br />
+* Ephrin-A3
+**[[3dzq]] – hEph kinase domain + inhibitor <br />
 *Ephrin-A5
-**[[1shx]] – mEph receptor-binding domain – mouse<br />
-**[[1shw]] – mEph residues 88-225 + Eph type B receptor 2 <br />
 **[[2x11]], [[3mx0]] – hEph receptor-binding domain + Eph type A receptor 2 - human<br />
 **[[4bk5]], [[4bka]], [[4m4r]] – hEph receptor-binding domain + Eph type A receptor 4 <br />
 **[[4l0p]] – hEph receptor-binding domain + Eph type A receptor 3 <br />
+**[[1shx]] – mEph receptor-binding domain – mouse<br />
+**[[1shw]] – mEph residues 88-225 + Eph type B receptor 2 <br />
+*Ephrin-B1
+**[[6thg]] – hEph extracellular domain 27-170 + glycoprotein <br />
+**[[6p7s]] – mEph extracellular domain + glycoprotein <br />
 *Ephrin-B2
 **[[2i85]] – hEph residues 1-142 – NMR<br />
-**[[1iko]] – mEph ectodomain <br />
+**[[2wo2]], [[3gxu]] – hEph extracellular domain + Eph type A receptor 4 <br />
-**[[1kgy]] – mEph receptor-binding domain + Eph type B receptor 2 <br />
+**[[4uf7]], [[6pdl]] – hEph extracellular domain + glycoprotein <br />
-**[[2hle]] – mEph receptor-binding domain + Eph type B receptor 4 <br />
+**[[2vsk]], [[2vsm]] – hEph extracellular domain + virus hemagglutinin neuraminidase <br />
-**[[2wo2]], [[3gxu]] – hEph receptor-binding domain + Eph type A receptor 4 <br />
+**[[1iko]], [[7s7k]] – mEph ectodomain <br />
-**[[2vsk]], [[2vsm]] – hEph receptor-binding domain + virus hemagglutinin neuraminidase <br />
+**[[1kgy]] – mEph extracellular domain + Eph type B receptor 2 <br />
+**[[2hle]] – mEph extracellular domain + Eph type B receptor 4 <br />
+**[[6p7y]] – mEph extracellular domain + glycoprotein <br />
 *Ephrin-B3
+**[[4bkf]] – hEph receptor-binding domain + Eph type A receptor 4 <br />
 **[[3d12]] – mEph receptor-binding domain + virus hemagglutinin neuraminidase <br />
-**[[4bkf]] – hEph receptor-binding domain + Eph type A receptor 4 <br />
-*Ephrin-A1
-**[[3hei]], [[3mbw]] – hEph receptor-binding domain + Eph type A receptor 2 <br />
-*Ephrin-A2
-**[[2wo3]] – hEph receptor-binding domain + Eph type A receptor 4 <br />
 }}