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Dehalogenase: Difference between revisions

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<StructureSection load='2edc' size='340' side='right' caption='Structure of haloalkane dehalogenase complex with I- ion (purple) (PDB code [[2edc]]).' scene=''>
<StructureSection load='' size='350' side='right' caption='Structure of haloalkane dehalogenase complex with I- ion (purple) (PDB code [[2edc]]).' scene='59/594596/Cv/1'>
__TOC__
__TOC__
== Function ==
== Function ==
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'''Dehalogenases''' catalyze the removal of halogen atom from substrates.<br />
'''Dehalogenases''' catalyze the removal of halogen atom from substrates.<br />
• '''Haloalkane dehalogenase''' converts haloalkanes to alcohol<ref>PMID:21294712</ref><br />
• '''Haloalkane dehalogenase''' converts haloalkanes to alcohol<ref>PMID:21294712</ref><br />
• '''Halohydrin dehalogenase''' converts halohydrins to epoxide<br />
• '''Halohydrin dehalogenase''' converts halohydrins to epoxide<ref>PMID:27502414</ref><br />
• '''L-2 haloacid dehalogenase''' converts L-2-haloacids to D-2-hydroxyacid<br />
• '''L-2 haloacid dehalogenase''' converts L-2-haloacids to D-2-hydroxyacid<ref>PMID:7629151</ref><br />
• '''S-2 haloacid dehalogenase''' converts S-2-haloacids to R-2-hydroxyacid<br />
• '''S-2 haloacid dehalogenase''' converts S-2-haloacids to R-2-hydroxyacid<br />
• '''4-chlorobenzoyl CoA dehalogenase''' converts 4-chlorobenzoyl CoA to 4-hydroxybenzoyl CoA <br />
• '''4-chlorobenzoyl CoA dehalogenase''' converts 4-chlorobenzoyl CoA to 4-hydroxybenzoyl CoA <ref>PMID:11493680</ref><br />
• '''Fluoroacetate dehalogenase''' converts fluoroacetate to glycolate<br />
• '''Fluoroacetate dehalogenase''' converts fluoroacetate to glycolate<ref>PMID:9812982</ref><br />
• '''Iodotyrosine dehalogenase''' converts iodotyrosine to tyrosine<br />
• '''Iodotyrosine dehalogenase''' converts iodotyrosine to tyrosine<ref>PMID:15289438</ref><br />
• '''cis- and trans-3-chloroacrylic acid dehalogenase''' converts 3-chloroacrylate to malonate semialdehyde<br />
• '''cis- and trans-3-chloroacrylic acid dehalogenase''' converts 3-chloroacrylate to malonate semialdehyde<br />
• '''5-chloromuconolactone dehalogenase''' converts 5-chloromuconolactone to E-dienelactone.<br />
• '''5-chloromuconolactone dehalogenase''' converts 5-chloromuconolactone to E-dienelactone<ref>PMID:23376735</ref><br />
• '''Tetrachloroethene reductive dehalogenase''' catalyzes the conversion of trichloroethene, Cl- and acceptor to tetrachloroethene and reduced acceptor.
• '''Tetrachloroethene reductive dehalogenase''' catalyzes the conversion of trichloroethene, Cl- and acceptor to tetrachloroethene and reduced acceptor<ref>PMID:9575235</ref>.


== Relevance ==
== Relevance ==


Haloalkane dehalogenase is tested for the biodegredation of toxic industrial by-products.  Fluoroacetate dehalogenase is tested for the biodegredation of the poisonous fluroacetate which can kill livestock and is found in some plants in Australia, Africa and Central America.
Haloalkane dehalogenase is tested for the biodegredation of toxic industrial by-products.  Fluoroacetate dehalogenase is tested for the biodegredation of the poisonous fluroacetate which can kill livestock and is found in some plants in Australia, Africa and Central America.  Halohydrin dehalogenase is used as a biocatalyst.


== Disease ==
Iodotyrosine dehalogenase mutation is involved in congenital hypothyroidism<ref>PMID:18765512</ref>.
== Structural highlights ==
== Structural highlights ==


In the fluoroacetate dehalogenase complex with halide, the iodide is seen in the active site cavity between two tryptophanes.<ref>PMID:8369276</ref>
In the fluoroacetate dehalogenase complex with halide, the <scene name='59/594596/Cv/5'>iodide is seen in the active site cavity between two tryptophans</scene> (in cyan).<ref>PMID:8369276</ref>
</StructureSection>


==3D structures of dehalogenase==
==3D structures of dehalogenase==
[[Dehalogenase 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Haloalkane dehalogenase (HDH)
 
**[[2had]], [[1ede]], [[2pky]], [[2yxp]] – XaHDH – ''Xanthobacter autotrophicus''<br />
**[[1hde]], [[1be0]], [[1bee]], [[1bez]] – XaHDH (mutant)<br />
**[[1bn6]], [[1bn7]], [[4kaa]], [[4kac]], [[4kaf]] – RrHDH – ''Rhodococcus rhodochrous'' <br />
**[[2v9z]], [[4wcv]] – RrHDH (mutant) <br />
**[[1cv2]] – SpHDH – ''Sphingomonas paucimobilis''<br />
**[[4h77]] – SphHDH – ''Sphignobium''<br />
**[[4h7d]], [[4h7k]] – SphHDH (mutant)<br />
**[[2xt0]] – HDH – ''Plesiocystis pacifica''<br />
**[[3wi7]] – AtHDH – ''Agrobacterium tumefaciens''<br />
**[[3wib]] – AtHHDH (mutant)<br />
 
*''Haloalkane dehalogenase complex with halide ion''
 
**[[1edb]], [[1edd]], [[2eda]], [[2edc]], [[2dhe]], [[1b6g]] – XaHDH + halide<br />
**[[1cij]] – XaHDH (mutant) + Br<br />
**[[1d07]], [[1iz7]], [[1k5p]], [[1mj5]] – SpHDH + halide <br />
**[[3fbw]], [[1cqw]], [[4hzg]] – RrHDH + halide <br />
**[[3a2m]], [[3a2n]], [[3afi]] – BjHDH + Cl – ''Bradyrhizobium japonicum''<br />
**[[3a2l]] – BjHDH (mutant) + Cl <br />
**[[4k2a]] – HDH + Cl – ''Bradyrhizobium elkanii''<br />
**[[3rk4]], [[3sk0]], [[4f5z]], [[4f60]] – RrHDH (mutant) + halide <br />
**[[4h7e]], [[4h7f]], [[4h7h]], [[4h7i]], [[4h7j]] [[4h7k]] – SphHDH (mutant) + halide <br />
**[[4brz]] – RhHDH + Cl - ''Rhodobacteraceae''<br />
**[[4mj3]] – HDH + Cl – ''Mycobacterium rhodesiae''<br />
 
*''Haloalkane dehalogenase other complexes''
 
**[[2dhc]] – XaHDH + ethylene dichloride<br />
**[[2dhd]] – XaHDH + amono-chloroethoxy-oxobutanoic acid + Cl<br />
**[[1g42]] – SpHDH + dichloropropane + Cl<br />
**[[2bfn]] – SpHDH + dichloropropanol + Cl<br />
**[[1g4h]] – SpHDH (mutant) + butanol + Cl<br />
**[[1g5f]] – SpHDH + dichloroethane + Cl<br />
**[[1iz8]] – SpHDH + propanediol + Cl<br />
**[[4c6h]] – RhHDH + hexanol + Cl<br />
**[[3fwh]], [[3g9x]], [[4e46]] – RrHDH + isopropanol + Cl <br />
**[[1k6e]] – SpHDH + bromopropanol + Cl + Br<br />
**[[1k63]] – SpHDH + bromopropene-1-ol + Cl + Br<br />
**[[4fwb]] – SpHDH (mutant) + trichloropropane + Cl<br />
**[[2o2h]] – MtHDH 3 + dichloroethane + Cl – ''Mycobacterium tuberculosis''<br />
**[[2o2i]] – MtHDH 3 + propanediol + Br<br />
**[[2qvb]] – MtHDH 3 + ethanediol + Cl<br />
 
*Fluoroacetate dehalogenase (FDH)
 
**[[1y37]] – BuFDH – ''Burkholderia''<br />
**[[3r3u]] – RpFDH – ''Rhodopseudomonas palustris''<br />
**[[3r40]], [[3r41]] – RpFDH (mutant) <br />
 
*''Fluoroacetate dehalogenase complexes''
 
**[[3r3v]], [[3r3y]] – RpFDH (mutant) + fluoroacetate<br />
**[[3r3w]] – RpFDH (mutant) + chloroacetate<br />
**[[3r3x]] – RpFDH (mutant) + bromoacetate<br />
**[[3r3z]] – RpFDH + glycolate<br />
**[[3b12]] – BuFDH (mutant) + fluoroacetate<br />
 
*Halohydrin dehalogenase (HHDH)
 
**[[1zmo]] – HHDH – ''Anthrobacter''<br />
**[[3zn2]] – AtHHDH <br />
 
*''Halohydrin dehalogenase complexes''
 
**[[1pwx]] – AtHHDH + Br <br />
**[[1px0]] – AtHHDH + haloalcohol mimic<br />
**[[1zo8]] – AtHHDH + p-nitrostyrene oxide<br />
**[[1pwz]], [[1zmt]] – AtHHDH + styrene oxide + Cl<br />
**[[4ixt]] – AtHHDH (mutant) + ethyl cyano-hydroxybutyrate<br />
**[[4ixw]] – RrHHDH (mutant) + ethyl oxiranyl acetate – ''Rhizobium radiobacter''<br />
**[[4iy1]] – RrHHDH + Cl<br />
 
*L-2-haloacid dehalogenase (LHDH)
 
**[[1jud]] – PsLHDH – ''Pseudomonas''<br />
**[[2w43]] – StLHDH – ''Sulfolobus tokodaii''<br />
**[[2yml]], [[2ymm]], [[2ymp]], [[2ymq]] – RhLHDH <br />
**[[4ce6]], [[4cf3]], [[4cf4]], [[4cf5]], [[4cnq]] – RhLHDH (mutant)<br />
**[[3bjx]] – LHDH – ''Pseudomonas putida'' <br />
**[[3umc]] – LHDH – ''Pseudomonas aeruginosa'' <br />
**[[3um9]] – LHDH – ''Polaromonas'' <br />
**[[3umg]] – LHDH – ''Rhodococcus jostii'' <br />
 
*''L-2-haloacid dehalogenase complexes''
 
**[[1aq6]], [[1qq5]] – XaLHDH + formic acid<br />
**[[1zrm]] – PsLHDH (mutant) + butanoic acid<br />
**[[1zrn]] – PsLHDH (mutant) + acetic acid<br />
**[[1qh9]] – PsLHDH + lactic acid<br />
**[[2w11]] – StLHDH + lactic acid <br />
**[[1qq6]], [[1qq7]] – XaLHDH + aspartate carboxymethyl ester + Cl<br />
**[[2yn4]] – RhLHDH + chlorobutyrate<br />
 
*DL-2-haloacid dehalogenase (DLHDH)
 
**[[4n2x]] – MeDLHDH – ''Methylobacterium''<br />
**[[3wj8]] – MeDLHDH + bromo-methylpropionate <br />
 
* S-2-haloacid dehalogenase (SHDH)
 
**[[2no4]] – BcSHDH IVA – ''Burkholderia cepacia''<br />
**[[2no5]] – BcSHDH IVA + 2-monochloroprapanate<br />
 
*Iodotyrosine dehalogenase (ITDH)
 
**[[3gb5]] – mITDH – mouse<br />
**[[3to0]] – mITDH (mutant) <br />
**[[3gfd]] – mITDH + iodotyrosine<br />
**[[3tnz]] – mITDH (mutant) + iodotyrosine<br />
**[[3gh8]] – mITDH + diiodotyrosine<br />
**[[4ttb]] – hITDH 1 + FMN<br />
**[[4ttc]] – hITDH 1 + FMN + iodotyrosine <br />
 
*cis-3-chloroacrylic acid dehalogenase (CaaD)
 
**[[2flz]], [[3mf8]] – CbCaaD – ''Coryneform bacterium''<br />
**[[3mf7]] – CbCaaD + oxirane-carboxylate <br />
**[[2flt]] – CbCaaD + lactic acid<br />
 
*trans-3-chloroacrylic acid dehalogenase (TaaD)
 
**[[3ej3]] – PpTaaD α+β subunits – ''Pseudomonas pavonacea''<br />
**[[3ej7]], [[3ej9]] – PpTaaD α (mutant) +β subunits <br />
**[[1s0y]] – PpTaaD α+β subunits + malonic acid <br />
 
*5-chloromuconolactone dehalogenase (ClcF)
 
**[[3znu]], [[3znj]], [[4fpi]] – RoClcF – ''Rhodococcus opacus'' <br />
**[[3zo7]] – RoClcF + 5-chloromuconolactone <br />
 
*4-chlorobenzoyl CoA dehalogenase (CBCD)
 
**[[1nzy]] – PsCBCD  <br />
**[[1jxz]] – PsCBCD + hydroxybenzoyl CoA <br />
 
*Tetrachloroethene reductive dehalogenase (TCRD)
 
**[[4uqu]], [[4ur3]] – SmTCRD catalytic subunit – ''Sulfurospirillum multivorans''<br />
**[[4ur0]] – SmTCRD catalytic subunit + trichloroethene<br />
**[[4ur1]] – SmTCRD catalytic subunit + tribromoethene<br />
**[[4ur2]] – SmTCRD catalytic subunit + iodide<br />
 
}}




Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman
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