Dehalogenase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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-<StructureSection load='2edc' size='340' side='right' caption='Structure of haloalkane dehalogenase complex with I- ion (purple) (PDB code [[2edc]]).' scene=''>
+<StructureSection load='' size='350' side='right' caption='Structure of haloalkane dehalogenase complex with I- ion (purple) (PDB code [[2edc]]).' scene='59/594596/Cv/1'>
+__TOC__
 == Function ==
 '''Dehalogenases''' catalyze the removal of halogen atom from substrates.<br />
-•	'''Haloalkane dehalogenase''' converts haloalkanes to alcohol<br />
+•	'''Haloalkane dehalogenase''' converts haloalkanes to alcohol<ref>PMID:21294712</ref><br />
-•	'''Halohydrin dehalogenase''' converts halohydrins to epoxide<br />
+•	'''Halohydrin dehalogenase''' converts halohydrins to epoxide<ref>PMID:27502414</ref><br />
-•	'''L-2 haloacid dehalogenase''' converts haloacids to hydroxyacid<br />
+•	'''L-2 haloacid dehalogenase''' converts L-2-haloacids to D-2-hydroxyacid<ref>PMID:7629151</ref><br />
-•	'''4-chlorobenzoyl CoA dehalogenase''' converts 4-chlorobenzoyl CoA to 4-hydroxybenzoyl CoA <br />
+•	'''S-2 haloacid dehalogenase''' converts S-2-haloacids to R-2-hydroxyacid<br />
-•	'''Fluoroacetate dehalogenase''' converts fluoroacetate to glycolate<br />
+•	'''4-chlorobenzoyl CoA dehalogenase''' converts 4-chlorobenzoyl CoA to 4-hydroxybenzoyl CoA <ref>PMID:11493680</ref><br />
-•	'''Iodotyrosine dehalogenase''' converts iodotyrosine to tyrosine<br />
+•	'''Fluoroacetate dehalogenase''' converts fluoroacetate to glycolate<ref>PMID:9812982</ref><br />
+•	'''Iodotyrosine dehalogenase''' converts iodotyrosine to tyrosine<ref>PMID:15289438</ref><br />
 •	'''cis- and trans-3-chloroacrylic acid dehalogenase''' converts 3-chloroacrylate to malonate semialdehyde<br />
-•	'''5-chloromuconolactone dehalogenase''' converts 5-chloromuconolactone to E-dienelactone.
+•	'''5-chloromuconolactone dehalogenase''' converts 5-chloromuconolactone to E-dienelactone<ref>PMID:23376735</ref><br />
+•	'''Tetrachloroethene reductive dehalogenase''' catalyzes the conversion of trichloroethene, Cl- and acceptor to tetrachloroethene and reduced acceptor<ref>PMID:9575235</ref>.
-== Disease ==
 == Relevance ==
-== Structural highlights ==
+Haloalkane dehalogenase is tested for the biodegredation of toxic industrial by-products.  Fluoroacetate dehalogenase is tested for the biodegredation of the poisonous fluroacetate which can kill livestock and is found in some plants in Australia, Africa and Central America.  Halohydrin dehalogenase is used as a biocatalyst.
-==3D structures of dehalogenase==
+== Disease ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+Iodotyrosine dehalogenase mutation is involved in congenital hypothyroidism<ref>PMID:18765512</ref>.
+== Structural highlights ==
-===Haloalkane dehalogenase (HDH)===
+In the fluoroacetate dehalogenase complex with halide, the <scene name='59/594596/Cv/5'>iodide is seen in the active site cavity between two tryptophans</scene> (in cyan).<ref>PMID:8369276</ref>
-[[2had]], [[1ede]], [[2pky]], [[2yxp]] – XaHDH – ''Xanthobacter autotrophicus''<br />
+==3D structures of dehalogenase==
-[[1hde]], [[1be0]], [[1bee]], [[1bez]] – XaHDH (mutant)<br />
+[[Dehalogenase 3D structures]]
-[[1bn6]], [[1bn7]], [[4kaa]], [[4kac]], [[4kaf]] – RrHDH – ''Rhodococcus rhodochrous'' <br />
-[[2v9z]] – RrHDH (mutant) <br />
-[[1cv2]] – SpHDH – ''Sphingomonas paucimobilis''<br />
-[[4h77]] – SphHDH – ''Sphignobium''<br />
-[[4h7d]] – SphHDH (mutant)<br />
-''Haloalkane dehalogenase complex with halide ion''
-[[1edb]], [[1edd]], [[2eda]], [[2edc]], [[2dhe]], [[1b6g]] – XaHDH + halide<br />
-[[1cij]] – XaHDH (mutant) + halide<br />
-[[1d07]], [[1iz7]], [[1k5p]], [[1mj5]] – SpHDH + halide <br />
-[[3fbw]], [[1cqw]], [[4hzg]] – RrHDH + halide <br />
-[[3a2m]], [[3a2n]], [[3afi]] – BjHDH + halide – ''Bradyrhizobium japonicum''<br />
-[[3a2l]] – BjHDH (mutant) + halide <br />
-[[4k2a]] – HDH + halide – ''Bradyrhizobium elkanii''<br />
-[[3rk4]], [[3sk0]], [[4f5z]], [[4f60]] – RrHDH (mutant) + halide <br />
-[[4h7e]], [[4h7f]], [[4h7h]], [[4h7i]], [[4h7j]] [[4h7k]] – SphHDH (mutant) + halide <br />
-[[4brz]] – RhHDH + halide - ''Rhodobacteraceae''<br />
-''Haloalkane dehalogenase other complexes''
-[[2dhc]] – XaHDH + ethylene dichloride<br />
-[[2dhd]] – XaHDH + amono-chloroethoxy-oxobutanoic acid + Cl<br />
-[[1g42]] – SpHDH + dichloropropane + Cl<br />
-[[2bfn]] – SpHDH + dichloropropanol + Cl<br />
-[[1g4h]] – SpHDH (mutant) + butanol + Cl<br />
-[[1g5f]] – SpHDH + dichloroethane + Cl<br />
-[[1iz8]] – SpHDH + propanediol + Cl<br />
-[[4c6h]] – RhHDH + hexanol + Cl<br />
-[[3fwh]], [[3g9x]], [[4e46]] – RrHDH + isopropanol + Cl <br />
-[[1k6e]] – SpHDH + bromopropanol + Cl + Br<br />
-[[1k63]] – SpHDH + bromopropene-1-ol + Cl + Br<br />
-[[4fwb]] – SpHDH (mutant) + trichloropropane + Cl<br />
-===Fluoroacetate dehalogenase (FDH)===
-[[1y37]] – BuFDH – ''Burkholderia''<br />
-[[3r3u]] – RpFDH – ''Rhodopseudomonas palustris''<br />
-[[3r40]], [[3r41]] – RpFDH (mutant) <br />
-''Fluoroacetate dehalogenase complexes''
-[[3r3v]], [[3r3y]] – RpFDH (mutant) + fluoroacetate<br />
-[[3r3w]] – RpFDH (mutant) + chloroacetate<br />
-[[3r3x]] – RpFDH (mutant) + bromoacetate<br />
-[[3r3z]] – RpFDH + glycolate<br />
-[[3b12]] – BuFDH (mutant) + fluoroacetate<br />
-===Halohydrin dehalogenase (HHDH)===
-[[1zmo]] – HHDH – ''Anthrobacter''<br />
-[[3zn2]] – AtHHDH – ''Agrobacterium tumefaciens''<br />
-''Halohydrin dehalogenase complexes''
-[[1pwx]] – AtHHDH + Br <br />
-[[1px0]] – AtHHDH + haloalcohol mimic<br />
-[[1zo8]] – AtHHDH + p-nitrostyrene oxide<br />
-[[4ixt]] – AtHHDH (mutant) + ethyl cyano-hydroxybutyrate<br />
-[[4ixw]] – RrHHDH (mutant) + ethyl oxiranyl acetate – ''Rhizobium radiobacter''<br />
-[[4iy1]] – RrHHDH + Cl<br />
-===L-2-haloacid dehalogenase (LHDH)===
-[[1jud]] – PsLHDH – ''Pseudomonas''<br />
-[[2w43]] – StLHDH – ''Sulfolobus tokodaii''<br />
-''L-2-haloacid dehalogenase complexes''
-[[1aq6]], [[1qq5]] – XaLHDH + formic acid<br />
-[[1zrm]] – PsLHDH (mutant) + butanoic acid<br />
-[[1zrn]] – PsLHDH (mutant) + acetic acid<br />
-[[1qh9]] – PsLHDH + lactic acid<br />
-[[2w11]] – StLHDH + lactic acid <br />
-[[1qq6]], [[1qq7]] – XaLHDH + aspartate carboxymethyl ester + Cl<br />
-===DL-2-haloacid dehalogenase (DLHDH)===
-[[4n2x]] – MeDLHDH – ''Methylobacterium''<br />
-[[3wj8]] – MeDLHDH + bromo-methylpropionate <br />
-===Iodotyrosine dehalogenase (ITDH)===
-[[3gb5]] – mITDH – mouse<br />
-[[3to0]] – mITDH (mutant) <br />
-[[3gfd]] – mITDH + iodotyrosine<br />
-[[3tnz]] – mITDH (mutant) + iodotyrosine<br />
-[[3gh8]] – mITDH + diiodotyrosine<br />
-===cis-3-chloroacrylic acid dehalogenase (CaaD)===
-[[2flz]], [[3mf8]] – CbCaaD – ''Coryneform bacterium''<br />
-[[3mf7]] – CbCaaD + oxirane-carboxylate <br />
-[[2flt]] – CbCaaD + lactic acid<br />
-===trans-3-chloroacrylic acid dehalogenase (TaaD)===
-[[3ej3]] – PpTaaD α+β subunits – ''Pseudomonas pavonacea''<br />
-[[3ej7]], [[3ej9]] – PpTaaD α (mutant) +β subunits <br />
-[[1s0y]] – PpTaaD α+β subunits + malonic acid <br />
-===5-chloromuconolactone dehalogenase (ClcF)===
-[[3znu]], [[3znj]], [[4fpi]] – RoClcF – ''Rhodococcus opacus'' <br />
-[[3zo7]] – RoClcF + 5-chloromuconolactone <br />
-===4-chlorobenzoyl CoA dehalogenase (CBCD)===
-[[1nzy]] – PsCBCD  <br />
-[[1jxz]] – PsCBCD + hydroxybenzoyl CoA <br />
+</StructureSection>