Complement C3: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-<StructureSection load='2icf' size='340' side='right' caption='Structure of human glycosylated complement C3b α (magenta) and β (salmon) chains complex with protein CRIG (khaki) and Ca+2 ion (green) (PDB code [[2icf]]).' scene='59/594590/Cv/1'>
+<StructureSection load='2icf' size='340' side='right' caption='Structure of human glycosylated complement C3b α (magenta) and β (salmon) chains complex with protein CRIG (cyan) and Ca+2 ion (green) (PDB code [[2icf]]).' scene='59/594590/Cv/1'>
 __TOC__
 == Function ==
-'''Complement C3''' (CC3) activates the complement system which is part of the immune response.  CC3 is proteolytically cleaved by C3 convertase to C3a (residues 672-748) and C3b (residues 23-667, 749-1663).  C3a is a mediator of local inflammatory processes.  C3b binds covalently to cell surface carbohydrates or immune aggregates.  Breakdown of C3b generates the fragment C3d (residues 996-1287) which binds to antigens enhancing their uptake by B cells.  C3c is another C3b cleavage product residues: 23-664, 749-954, 1321-1663.<ref>PMID:11414361</ref>
+'''Complement C3''' (CC3) activates the complement system which is part of the immune response.  '''CC3''' is proteolytically cleaved by C3 convertase to '''C3a''' (residues 672-748) and '''C3b''' (residues 23-667, 749-1663).
+*'''C3a''' is a mediator of local inflammatory processes.
+*'''C3b''' binds covalently to cell surface carbohydrates or immune aggregates.
+*'''C3c''' is another C3b cleavage product residues: 23-664, 749-954, 1321-1663.<ref>PMID:11414361</ref>
+*'''C3d''' is a fragment generated by C3b(residues 996-1287) which binds to antigens enhancing their uptake by B cells<ref>PMID:17337780</ref>.
+<scene name='59/594590/Cv/2'>C3b α and β chains with protein CRIG and Ca+2 ion</scene>.
+<scene name='59/594590/Cv/4'>Ca+2 ion coordination site</scene> (PDB code [[2icf]]).<ref>PMID:17051150</ref>
 == Disease ==
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 Low levels of CC3 in the blood are associated with some kidney diseases.
-</StructureSection>
 ==3D structures of complement C3==
+[[Complement C3 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Complement C3
-**[[2a73]] – hCC3 – human <br />
-**[[1ghq]] – hCC3 residues 996-1300 + Epstein-Barr virus receptor <br />
-**[[2b39]] – bCC3 – bovine <br />
-*Complement C3a (anaphylatoxin)
-**[[4hw5]], [[4hwj]], [[4i6o]] – hCC3  <br />
-*Complement C3b
-**[[2hr0]], [[2i07]] – hCC3  β+α’ chains<br />
-**[[2icf]] – hCC3 α+β chains + protein CRIG<br />
-**[[3g6j]] – hCC3 α+β chains + antibody<br />
-**[[2xwb]] – hCC3 α+β chains + complement factor B + complement factor D<br />
-**[[2xwj]] – hCC3 α+β chains (mutant) + complement factor B<br />
-**[[2wii]] – hCC3 α+β chains + complement factor H 1-4 sushi domains<br />
-**[[3l5n]], [[3ohx]] – hCC3 α+β chains + staphylococcal complement inhibitor<br />
-**[[2win]] – hCC3 α+β chains + complement factor B BB fragment + staphylococcal complement inhibitor<br />
-*Complement C3c
-**[[2a74]] – hCC3  <br />
-**[[2qki]] – hCC3 + compstatin <br />
-**[[3l3o]], [[3nms]] – hCC3 + staphylococcal complement inhibitor<br />
-**[[2ice]] – hCC3 α+β chains + protein CRIG<br />
-**[[3t4a]] – hCC3 α+β chains + fibrinogen-binding protein <br />
-*Complement C3d
-**[[1c3d]] – hCC3 (mutant) <br />
-**[[1w2s]], [[3oed]] – hCC3 1-2 sushi domains + complement receptor type 2 precursor<br />
-**[[2gox]], [[3d5r]], [[3d5s]] – hCC3 α chain fragment + fibrinogen-binding protein <br />
-**[[2noj]] – hCC3 α chain fragment (mutant) + EFB homologous protein <br />
-**[[2wy7]], [[2wy8]] – hCC3 α chain fragment (mutant) + IGG-binding protein <br />
-**[[3oxu]] – hCC3 α chain fragment (mutant) + HF protein <br />
-**[[4m76]] – hCC3 α chain fragment (mutant) + integrin α-M <br />
-**[[2xqw]] – hCC3  + complement factor H 19-20 sushi domains<br />
-**[[3rj3]] – hCC3 α chain fragment + complement factor H-related protein<br />
-**[[1qqf]] – rCC3 G fragment - rat <br />
-**[[1qsj]] – rCC3 G fragment (mutant) <br />
-}}
 == References ==