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| <StructureSection load='2icf' size='340' side='right' caption='Structure of human glycosylated complement C3b α (grey) and β (green) chains complex with protein CRIG (khaki) and Ca+2 ion (green) (PDB code [[2icf]]).' scene=''> | | <StructureSection load='2icf' size='340' side='right' caption='Structure of human glycosylated complement C3b α (magenta) and β (salmon) chains complex with protein CRIG (cyan) and Ca+2 ion (green) (PDB code [[2icf]]).' scene='59/594590/Cv/1'> |
| | __TOC__ |
| | == Function == |
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| == Function == | | '''Complement C3''' (CC3) activates the complement system which is part of the immune response. '''CC3''' is proteolytically cleaved by C3 convertase to '''C3a''' (residues 672-748) and '''C3b''' (residues 23-667, 749-1663). |
| | *'''C3a''' is a mediator of local inflammatory processes. |
| | *'''C3b''' binds covalently to cell surface carbohydrates or immune aggregates. |
| | *'''C3c''' is another C3b cleavage product residues: 23-664, 749-954, 1321-1663.<ref>PMID:11414361</ref> |
| | *'''C3d''' is a fragment generated by C3b(residues 996-1287) which binds to antigens enhancing their uptake by B cells<ref>PMID:17337780</ref>. |
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| | <scene name='59/594590/Cv/2'>C3b α and β chains with protein CRIG and Ca+2 ion</scene>. |
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| '''Complement C3''' (CC3) activates the complement system which is part of the immune response. CC3 is proteolytically cleaved by C3 convertase to C3a (residues 672-748) and C3b (residues 23-667, 749-1663). C3a is a mediator of local inflammatory processes. C3b binds covalently to cell surface carbohydrates or immune aggregates. Breakdown of C3b generates the fragment C3d (residues 996-1287) which binds to antigens enhancing their uptake by B cells. C3c is another C3b cleavage product residues: 23-664, 749-954, 1321-1663. | | <scene name='59/594590/Cv/4'>Ca+2 ion coordination site</scene> (PDB code [[2icf]]).<ref>PMID:17051150</ref> |
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| == Disease == | | == Disease == |
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| | A mutation in CC3 cause the progressive kidney disease: dense deposit disease. Other mutations are associated with recurrent bacterial infections. |
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| == Relevance == | | == Relevance == |
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| == Structural highlights ==
| | Low levels of CC3 in the blood are associated with some kidney diseases. |
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| ==3D structures of complement C3== | | ==3D structures of complement C3== |
| | [[Complement C3 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
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| ===CC3===
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| [[2a73]] – hCC3 – human <br />
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| [[2b39]] – bCC3 – bovine <br />
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| ===CC3a (anaphylatoxin)===
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| [[4hw5]], [[4hwj]], [[4i6o]] – hCC3 <br />
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| ===CC3b===
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| [[2hr0]], [[2i07]] – hCC3 β+α’ chains<br />
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| [[2icf]] – hCC3 α+β chains + protein CRIG<br />
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| [[3g6j]] – hCC3 α+β chains + antibody<br />
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| [[2xwb]] – hCC3 α+β chains + complement factor B + complement factor D<br />
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| [[2xwj]] – hCC3 α+β chains (mutant) + complement factor B<br />
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| [[2wii]] – hCC3 α+β chains + complement factor H 1-4 sushi domains<br />
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| [[3l5n]], [[3ohx]] – hCC3 α+β chains + staphylococcal complement inhibitor<br />
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| [[2win]] – hCC3 α+β chains + complement factor B BB fragment + staphylococcal complement inhibitor<br />
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| ===CC3c===
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| [[2a74]] – hCC3 <br />
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| [[2qki]] – hCC3 + compstatin <br />
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| [[3l3o]], [[3nms]] – hCC3 + staphylococcal complement inhibitor<br />
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| [[2ice]] – hCC3 α+β chains + protein CRIG<br />
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| [[3t4a]] – hCC3 α+β chains + fibrinogen-binding protein <br />
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| ===CC3d===
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| [[1c3d]] – hCC3 (mutant) <br />
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| [[1w2s]], [[3oed]] – hCC3 1-2 sushi domains + complement receptor type 2 precursor<br />
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| [[2gox]], [[3d5r]], [[3d5s]] – hCC3 α chain fragment + fibrinogen-binding protein <br />
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| [[2noj]] – hCC3 α chain fragment (mutant) + EFB homologous protein <br />
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| [[2wy7]], [[2wy8]] – hCC3 α chain fragment (mutant) + IGG-binding protein <br />
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| [[3oxu]] – hCC3 α chain fragment (mutant) + HF protein <br />
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| [[4m76]] – hCC3 α chain fragment (mutant) + integrin α-M <br />
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| [[2xqw]] – hCC3 + complement factor H 19-20 sushi domains<br />
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| [[3rj3]] – hCC3 α chain fragment + complement factor H-related protein<br />
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| [[1qqf]] – rCC3 G fragment - rat <br />
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| [[1qsj]] – rCC3 G fragment (mutant) <br />
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| == References == | | == References == |