Intercellular adhesion molecule: Difference between revisions

Latest revision as of 10:44, 4 July 2024

Function

Intercellular adhesion molecule (ICAM) is part of the immunoglobulin superfamily. ICAM binds to leukocyte function associated molecule 1 (LFA-1) and macrophage-1 antigen during inflammation^[1]. ICAM contains 5 Ig-like domains.

ICAM-1 is Ig-like cell adhesion molecule which has a role in inflammatory processes and in T-cell mediated host defines system.
ICAM-2 mediates adhesive interactions important for antigen-specific immune response.
ICAM-3 acts as recognition receptor in the phagocytosis of macrophages in engulfment of apoptotic neutrophils^[2].
ICAM-5 has 2 types of binding activities: binding between neutrons and binding between neuron and leukocytes.

Disease

ICAM mutation is involved in multiple sclerosis^[3].

Structure of glycosylated human ICAM-1 domains 1-2 (grey) complex with LFA-1 (green) and Mg+2 ion (green) (PDB code 1mq8).

Drag the structure with the mouse to rotate

3D structures of intercellular adhesion molecule3D structures of intercellular adhesion molecule

Updated on 04-July-2024

ReferencesReferences

↑ van de Stolpe A, van der Saag PT. Intercellular adhesion molecule-1. J Mol Med (Berl). 1996 Jan;74(1):13-33. PMID:8834767
↑ Kristóf E, Zahuczky G, Katona K, Doró Z, Nagy É, Fésüs L. Novel role of ICAM3 and LFA-1 in the clearance of apoptotic neutrophils by human macrophages. Apoptosis. 2013 Oct;18(10):1235-51. PMID:23775590 doi:10.1007/s10495-013-0873-z
↑ Nejentsev S, Laaksonen M, Tienari PJ, Fernandez O, Cordell H, Ruutiainen J, Wikstrom J, Pastinen T, Kuokkanen S, Hillert J, Ilonen J. Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis. Hum Immunol. 2003 Mar;64(3):345-9. PMID:12590979

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

[1] van de Stolpe A, van der Saag PT. Intercellular adhesion molecule-1. J Mol Med (Berl). 1996 Jan;74(1):13-33. PMID:8834767

[2] Kristóf E, Zahuczky G, Katona K, Doró Z, Nagy É, Fésüs L. Novel role of ICAM3 and LFA-1 in the clearance of apoptotic neutrophils by human macrophages. Apoptosis. 2013 Oct;18(10):1235-51. PMID:23775590 doi:10.1007/s10495-013-0873-z

[3] Nejentsev S, Laaksonen M, Tienari PJ, Fernandez O, Cordell H, Ruutiainen J, Wikstrom J, Pastinen T, Kuokkanen S, Hillert J, Ilonen J. Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis. Hum Immunol. 2003 Mar;64(3):345-9. PMID:12590979

[1]

[2]

[3]

@@ Line 6: / Line 6: @@
 *'''ICAM-1''' is Ig-like cell adhesion molecule which has a role in inflammatory processes and in T-cell mediated host defines system.
+*'''ICAM-2''' mediates adhesive interactions important for antigen-specific immune response.
+*'''ICAM-3''' acts as recognition receptor in the phagocytosis of macrophages in engulfment of apoptotic neutrophils<ref>PMID:23775590</ref>.
+*'''ICAM-5''' has 2 types of binding activities: binding between neutrons and binding between neuron and leukocytes.
 == Disease ==