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| <StructureSection load='2c8c' size='340' side='right' caption='Structure of exoenzyme C3 catalytic domain complex with ADP and NAD (PDB code [[2c8c]]).' scene=''> | | <StructureSection load='2c8c' size='400' side='right' caption='Structure of exoenzyme C3 catalytic domain complex with ADP and NAD (PDB code [[2c8c]]).' scene='59/593306/Cv/8'> |
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| == Function ==
| | '''Exoenzymes''' (Exo) are secreted by cells and break large macromolecules outside the cells. The breakdown components can pass through the cell wall. |
| | *'''Exo C3''' is a ''Clostridium butulinum'' toxin which binds [[NAD]], splits it into ADP-ribose and nicotinamide and transfers the ADP-ribose to a protein substrate. |
| | * '''Exo S''' and '''Exo T''' are secreted by ''Pseudomonas aeruginosa'' and has GTPase-activating activity as well as ADP-ribosyltransferase activity<ref>PMID:11114250</ref> . |
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| '''Exoenzymes''' (Exo) are secreted by cells and break large macromolecules outside the cells. The breakdown components can pass through the cell wall. '''Exo C3''' is a ''Clostridium butulinum'' toxin which binds NAD, splits it into ADP-ribose and nicotinamide and transfers the ADP-ribose to a protein substrate. '''Exo S''' and '''Exo T''' are secreted by ''Pseudomonas aeruginosa'' and has GTPase-activating activity as well as ADP-ribosyltransferase activity. | | <scene name='59/593306/Cv/6'>NAD binding site</scene>. |
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| == Disease == | | <scene name='59/593306/Cv/7'>ADP binding site</scene> in exoenzyme C3 catalytic domain (PDB code [[2c8c]]). <ref>PMID:18369192</ref> |
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| == Relevance == | | ==3D structures of exoenzyme== |
| | [[Exoenzyme 3D structures]] |
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| == Structural highlights ==
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| </StructureSection> | | </StructureSection> |
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| ==3D structures of exoenzyme==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Exoenzyme C3
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| **[[1g24]] – CbExo residues 8-218 – ''Clostridium butulinum''<br />
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| **[[1uzi]], [[1r45]], [[1r4b]], [[2c89]] – CbExo catalytic domain <br />
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| **[[1gze]], [[2c8b]], [[2c8d]], [[2c8e]], [[2c8g]] – CbExo catalytic domain (mutant)<br />
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| **[[3bw8]] - Exo catalytic domain - ''Clostridium limosum''<br />
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| *Exoenzyme C3 complexes
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| **[[1gzf]] – CbExo catalytic domain + pyridinium derivative + ADP + NAD<br />
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| **[[2bov]] – CbExo + GDP + Ral-A GTPase<br />
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| **[[2a78]] – CbExo catalytic domain + GDP + Ral-A GTPase<br />
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| **[[2a9k]] – CbExo catalytic domain+ GDP + Ral-A GTPase + NAD<br />
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| **[[2c8a]] – CbExo catalytic domain + nicotinamide<br />
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| **[[2c8c]] – CbExo catalytic domain (mutant) + ADP + NAD<br />
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| **[[2c8f]], [[2c8h]] – CbExo catalytic domain (mutant) + NAD<br />
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| *Exoenzyme S
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| **[[1r4t]] – PaExo GAP domain – ''Pseudomonas aeruginosa'' - NMR<br />
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| **[[1he1]] – PaExo GAP domain + Ras-like protein + GDP <br />
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| **[[1he9]] – PaExo GAP domain + Ras-like protein <br />
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| *Exoenzyme T
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| **[[4jmf]] – PaExo residues 28-77 + chaperone<br />
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| }}
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| </StructureSection>
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| == References == | | == References == |
| <references/> | | <references/> |
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |