Exoenzyme: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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+<StructureSection load='2c8c' size='400' side='right' caption='Structure of exoenzyme C3 catalytic domain complex with ADP and NAD (PDB code [[2c8c]]).' scene='59/593306/Cv/8'>
-<StructureSection load='2c8c' size='340' side='right' caption='Structure of exoenzyme C3 catalytic domain complex with ADP and NAD (PDB code [[2c8c]]).' scene=''>
+'''Exoenzymes''' (Exo) are secreted by cells and break large macromolecules outside the cells.  The breakdown components can pass through the cell wall.
+*'''Exo C3''' is a ''Clostridium butulinum'' toxin which binds [[NAD]], splits it into ADP-ribose and nicotinamide and transfers the ADP-ribose to a protein substrate.
+* '''Exo S''' and '''Exo T''' are secreted by ''Pseudomonas aeruginosa'' and has GTPase-activating activity as well as ADP-ribosyltransferase activity<ref>PMID:11114250</ref> .
-== Function ==
+<scene name='59/593306/Cv/6'>NAD binding site</scene>.
-'''Exoenzymes''' (Exo) are secreted by cells and break large macromolecules outside the cells.  The breakdown components can pass through the cell wall.  '''Exo C3''' is a ''Clostridium butulinum'' toxin which binds NAD, splits it into ADP-ribose and nicotinamide and transfers the ADP-ribose to a protein substrate.  '''Exo S''' and '''Exo T''' are secreted by ''Pseudomonas aeruginosa'' and has GTPase-activating activity as well as ADP-ribosyltransferase activity.
+<scene name='59/593306/Cv/7'>ADP binding site</scene> in exoenzyme C3 catalytic domain (PDB code [[2c8c]]). <ref>PMID:18369192</ref>
-== Disease ==
-== Relevance ==
-== Structural highlights ==
 ==3D structures of exoenzyme==
+[[Exoenzyme 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-'''Exoenzyme C3'''
-[[1g24]] – CbExo residues 8-218 – ''Clostridium butulinum''<br />
-[[1uzi]], [[1r45]], [[1r4b]], [[2c89]] – CbExo catalytic domain <br />
-[[1gze]], [[2c8b]], [[2c8d]], [[2c8e]], [[2c8g]] – CbExo catalytic domain (mutant)<br />
-[[3bw8]] - Exo catalytic domain - ''Clostridium limosum''<br />
-''Exoenzyme C3 complexes''
-[[1gzf]] – CbExo catalytic domain + pyridinium derivative + ADP + NAD<br />
-[[2bov]] – CbExo + GDP + Ral-A GTPase<br />
-[[2a78]] – CbExo catalytic domain + GDP + Ral-A GTPase<br />
-[[2a9k]] – CbExo catalytic domain+ GDP + Ral-A GTPase + NAD<br />
-[[2c8a]] – CbExo catalytic domain + nicotinamide<br />
-[[2c8c]] – CbExo catalytic domain (mutant) + ADP + NAD<br />
-[[2c8f]], [[2c8h]] – CbExo catalytic domain (mutant) + NAD<br />
-'''Exoenzyme S'''
-[[1r4t]] – PaExo GAP domain – ''Pseudomonas aeruginosa'' - NMR<br />
-[[1he1]] – PaExo GAP domain + Ras-like protein + GDP <br />
-[[1he9]] – PaExo GAP domain + Ras-like protein <br />
-'''Exoenzyme T'''
-[[4jmf]] – PaExo residues 28-77 + chaperone<br />
-</StructureSection>
 == References ==
 <references/>
 [[Category:Topic Page]]