Exportin: Difference between revisions
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<StructureSection load='3icq' size='400' side='right' caption='Structure of yeast exportin-5 (magenta) complex with GTPaseRan (cyan), Mg+2 (green) and RNA (PDB code [[3icq]]).' scene='59/592125/Cv/9'> | <StructureSection load='3icq' size='400' side='right' caption='Structure of yeast exportin-5 (magenta) complex with GTPaseRan (cyan), Mg+2 (green) and RNA (PDB code [[3icq]]).' scene='59/592125/Cv/9'> | ||
'''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. '''XPO-t''' | '''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. <br /> | ||
*'''XPO-1''' mediates nuclear transport of cellular proteins bearing a Leu-rich nuclear export signal and of RNA<ref>PMID:36727672</ref>.<br /> | |||
*'''XPO-4''' mediates nuclear transport of eukaryotic translation initiation factor 5A<ref>PMID:10944119</ref>.<br /> | |||
*'''XPO-5''' mediates nuclear transport of pre-miroRNAs and short hairpin RNAs<ref>PMID:14681208</ref>.<br /> | |||
*'''XPO-t''' or '''karyopherin''' is a nuclear transport receptor involved in the export of tRNA to the cytoplasm<ref>PMID:22944664</ref>.<br /> | |||
==Structural highlights == | ==Structural highlights == | ||