Undecaprenyl pyrophosphate synthase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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 == Function ==
-'''Undecaprenyl pyrophosphate synthase''' (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall<ref>PMID:15788389</ref>.  Bisphosphonate drugs are UPP inhibitors.
+'''Undecaprenyl pyrophosphate synthase''' or '''isoprenyl transferase''' or '''poly-cis-prenyltransferase''' or '''ditrans,polycis-undecaprenyl pyrophosphate synthase ((2E,6E) farnesyl diphosphate specific)''' (UPPS) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall<ref>PMID:15788389</ref>.  '''UPPS''' or '''NUS1''' is a subunit  of ''cis''-prenyltransferase<ref>PMID:27402831</ref>.  Bisphosphonate drugs are UPP inhibitors.
 == Relevance ==
-UPP inhibitors are investigated as potential antibacterials<ref>PMID:26718796</ref>.
+UPPS inhibitors are investigated as potential antibacterials<ref>PMID:26718796</ref>.
 == Structural highlights ==
-The <scene name='59/591995/Cv/3'>active site</scene> of UPP contains an <scene name='59/591995/Cv/1'>octahedrally coordinated Mg+2 ion bound to the pyrophosphate group of isopentenyl pyrophosphate</scene><ref>PMID:15788389</ref>. Water molecules shown as red spheres.
+The <scene name='59/591995/Cv/5'>active site</scene> of UPPS (water molecules are shown as red spheres) contains an <scene name='59/591995/Cv/6'>octahedrally coordinated Mg+2 ion bound to the pyrophosphate group of isopentenyl pyrophosphate</scene><ref>PMID:15788389</ref>.
-</StructureSection>
 ==3D structures of undecaprenyl pyrophosphate synthase==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+[[Undecaprenyl pyrophosphate synthase 3D structures]]
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Undecaprenyl pyrophosphate synthase
-**[[1f75]] – UPP (mutant) – ''Micrococcus luteus''<br />
-**[[3qas]], [[5cqb]], [[5oon]], [[6cb2]] – EcUPP – ''Escherichia coli''<br />
-**[[1jp3]] – EcUPP (mutant) <br />
-**[[2d2r]] – HpUPP (mutant) – ''Helicobacter pylori''<br />
-**[[2vg4]] – MtUPP – ''Mycobacterium tuberculosis''<br />
-**[[5kh2]] – SpUPP – ''Streptococcus pneumoniae''<br />
-**[[3wyi]] – SaUPP - ''Staphylococcus aureus'' <br />
-**[[5xk3]] – StUPP – ''Streptmyces''<br />
-*Undecaprenyl pyrophosphate synthase complexes
-**[[1ueh]] – EcUPP + Mg + SO4 + triton<br />
-**[[1v7u]] – EcUPP + FPP <br />
-**[[4u82]] – EcUPP + Mg + FPP derivative<br />
-**[[1x06]] – EcUPP + Mg + FPP analog + IPP<br />
-**[[1x08]] – EcUPP (mutant) + Mg + FPP analog + IPP<br />
-**[[1x07]] – EcUPP + Mg + PO4 + IPP<br />
-**[[1x09]] – EcUPP (mutant) + Mg + IPP<br />
-**[[2e98]], [[2e99]], [[2e9a]], [[2e9c]], [[2e9d]], [[3th8]], [[3sgt]], [[3sgv]], [[3sgx]], [[3sh0]], [[4h2j]], [[4h2m]], [[4h2o]], [[4h38]], [[4h3c]], [[4h3a]], [[4h8e]], [[3wyj]] – EcUPP + bisphosphonate<br />
-**[[5cqj]] – EcUPP + inhibitor <br />
-**[[5kh4]] – SpUPP + FPP <br />
-**[[5kh5]] – SpUPP + inhibitor <br />
-**[[2dtn]] – HpUPP + pyrophosphate<br />
-**[[3ugs]] - UPP + FPP analog – ''Campylobacter jejuni''<br />
-**[[2vg2]] – MtUPP + Pi + PPi + methyl butenyl diphosphate <br />
-**[[2vg3]] – MtUPP + Pi + Mg + geranyl diphosphate <br />
-**[[5xk8]] – StUPP + GPP <br />
-**[[5xk6]] – StUPP + IPP <br />
-**[[5xk7]] – StUPP + DMAPP <br />
-**[[5xk9]] – StUPP + GSPP + DMAPP <br />
-}}
 == References ==
 <references/>
+</StructureSection>
 [[Category:Topic Page]]